UniProt Q9H3R0
Lysine-specific demethylase 4C (Q9H3R0)
Lysine-specific demethylase 4C (UniProt Q9H3R0), EC 1.14.11.-: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9H3R0
- Protein
- Lysine-specific demethylase 4C
- EC
- 1.14.11.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 2 records with a druggable one
Structures
13 records of Q9H3R0 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XDP | Crystal structure of the tudor domain of human JMJD2C | x-ray diffraction | A | — | — |
| 2XDP | Crystal structure of the tudor domain of human JMJD2C | x-ray diffraction | A | — | — |
| 2XML | Crystal structure of human JMJD2C catalytic domain | x-ray diffraction | A, B | — | — |
| 2XML | Crystal structure of human JMJD2C catalytic domain | x-ray diffraction | A, B | — | — |
| 4XDO | Crystal structure of human KDM4C catalytic domain with OGA | x-ray diffraction | A, B | — | — |
| 4XDO | Crystal structure of human KDM4C catalytic domain with oga | x-ray diffraction | A, B | — | — |
| 4XDP | Crystal structure of human KDM4C catalytic domain bound to tris | x-ray diffraction | A, B | — | — |
| 4XDP | Crystal structure of human KDM4C catalytic domain bound to tris | x-ray diffraction | A, B | — | — |
| 5FJH | Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic compound… | x-ray diffraction | A, B | — | — |
| 5FJK | Crystal structure of human JMJD2C catalytic domain in complex… | x-ray diffraction | A | — | — |
| 5KR7 | KDM4C bound to pyrazolo-pyrimidine scaffold | x-ray diffraction | A, B | FE2, ZN, 6X9, CL | 6 (best 0.73) |
| 5KR7 | KDM4C bound to pyrazolo-pyrimidine scaffold | x-ray diffraction | A, B | FE2, ZN, 6X9, CL | — |
| Q9H3R0 | AlphaFold monomer V2.0 prediction for lysine-specific demethylase 4C (Q9H3R0) | predicted | A | — | 11 (best 0.82) |
Ligands
Experiment against prediction
- 4XDO chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 4XDO chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 4XDP chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 4XDP chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 2XML chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 2XML chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.69 Å
- 5KR7 chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.70 Å
- 5KR7 chain A against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.70 Å
- 5KR7 chain B against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.70 Å
- 5KR7 chain B against the predicted model Q9H3R0: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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