MMK · 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid

Binding sites

MMK in 12 structures; the first of them:

• 4UF0 · Crystal structure of JmjC domain of human histone demethylase UTY in complex with… · MMK A2268 · binds PHE1031, ASN1034, GLN1080, TYR1082, LYS1084, THR1090, HIS1093, GLN1094 and 7 more
• 5A3T · Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49… · MMK A1756 · binds ARG98, VAL99, TYR425, ASP428, TRP486, TYR488, PHE496, HIS499 and 9 more
• 5FJH · Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic… · MMK A1349 · binds TYR134, ASP137, TYR177, TYR179, PHE187, HIS190, GLU192, ASP193 and 8 more
• 5FPV · Crystal structure of human JMJD2A in complex with compound KDOAM20A · MMK A1358 · binds TYR133, ASP136, TYR176, TYR178, PHE186, HIS189, GLU191, ASP192 and 8 more
• 5FWJ · Crystal structure of human JARID1C in complex with KDM5-C49 · MMK A1775 · binds TYR440, ASP443, GLY496, TRP501, TYR503, PHE511, HIS514, GLU516 and 7 more
• 5ISL · Linked KDM5A Jmj Domain Bound to the Inhibitor C49… · MMK A601 · binds TYR409, ASP412, TRP470, TYR472, PHE480, HIS483, GLU485, ASN493 and 6 more
• 4UF0 · Crystal structure of jmjc domain of human histone demethylase uty in complex with… · MMK A2268 · binds PHE1031, ASN1034, GLN1080, TYR1082, LYS1084, THR1090, HIS1093, GLN1094 and 7 more
• 5A3T · Crystal structure of human plu-1 (JARID1B) in complex with KDM5-C49… · MMK A1756 · binds ARG98, VAL99, TYR425, ASP428, TRP486, TYR488, PHE496, HIS499 and 9 more
• 5FJH · Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic… · MMK A1349 · binds TYR134, ASP137, TYR177, TYR179, PHE187, HIS190, GLU192, ASP193 and 8 more
• 5FPV · Crystal structure of human JMJD2A in complex with compound KDOAM20A · MMK A1358 · binds TYR133, ASP136, TYR176, TYR178, PHE186, HIS189, GLU191, ASP192 and 8 more
• 5FWJ · Crystal structure of human JARID1C in complex with KDM5-C49 · MMK A1775 · binds TYR440, ASP443, GLY496, TRP501, TYR503, PHE511, HIS514, GLU516 and 7 more
• 5ISL · Linked KDM5A jmj domain bound to the inhibitor C49 (2-{[(2-{[(E)-2… · MMK A601 · binds TYR409, ASP412, TRP470, TYR472, PHE480, HIS483, GLU485, ASN493 and 6 more

Residues it binds most

TYR 32, ASN 32, HIS 32, LYS 32, ASP 28, TRP 32, GLU 32, PHE 32, SER 20, THR 24 (residue and the binding sites it lines).

Found with

• ZN · Zinc ion
• MN · Manganese (II) ion
• EDO · 1,2-ethanediol
• NI · Nickel (II) ion
• FE2 · Fe (II) ion
• MG · Magnesium ion
• CL · Chloride ion
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
• GOL · Glycerol