UniProt Q9H3N8
Histamine H4 receptor (Q9H3N8)
Histamine H4 receptor (UniProt Q9H3N8): 6 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H3N8
- Protein
- Histamine H4 receptor
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 31 · 5 records with a druggable one
Structures
7 records of Q9H3N8 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7YFC | Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex | electron microscopy | R | HSM, CLR | 5 (best 0.75) |
| 7YFD | Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex | electron microscopy | R | ITF, CLR | — |
| 8HN8 | Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex | electron microscopy | R | HSM | 7 (best 0.76) |
| 8JXT | Histamine-bound H4R/Gi complex | electron microscopy | R | HSM, PO4 | 5 (best 0.77) |
| 8JXW | VUF6884-bound H4R/Gi complex | electron microscopy | R | VCF | 7 (best 0.81) |
| 8JXX | Clobenpropit-bound H4R/Gi complex | electron microscopy | R | VCL | 7 (best 0.82) |
| Q9H3N8 | AlphaFold monomer V2.0 prediction for histamine H4 receptor (Q9H3N8) | predicted | A | — | — |
Ligands
- HSM · Histamine · in 3 records
- CLR · Cholesterol · in 2 records
- ITF · 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate · in 1 record
- PO4 · Phosphate ion · in 1 record
- VCF · 2-chloranyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine · in 1 record
- VCL · 3-(1~{H}-imidazol-4-yl)propyl ~{N}'-[(4-chlorophenyl)methyl]carbamimidothioate · in 1 record
Experiment against prediction
- 7YFD chain R against the predicted model Q9H3N8: TM-score 0.91, RMSD 2.28 Å
- 7YFC chain R against the predicted model Q9H3N8: TM-score 0.90, RMSD 2.34 Å
- 8JXX chain R against the predicted model Q9H3N8: TM-score 0.90, RMSD 2.49 Å
- 8JXW chain R against the predicted model Q9H3N8: TM-score 0.89, RMSD 2.35 Å
- 8HN8 chain R against the predicted model Q9H3N8: TM-score 0.89, RMSD 2.34 Å
- 8JXT chain R against the predicted model Q9H3N8: TM-score 0.89, RMSD 2.55 Å
- 8HN8 chain R against the predicted model P0ABE7: TM-score 0.27, RMSD 4.52 Å
Elsewhere
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