UniProt Q9H3D4
Tumor protein 63 (Q9H3D4)
Tumor protein 63 (UniProt Q9H3D4), EC 2.3.1.-, 2.3.1.48: 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 122 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9H3D4
- Protein
- Tumor protein 63
- EC
- 2.3.1.-, 2.3.1.48
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 122 · 14 records with a druggable one
Structures
47 records of Q9H3D4 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RG6 | Solution structure of the C-terminal domain of p63 | solution nmr | A | — | — |
| 1RG6 | Solution structure of the C-terminal domain of P63 | solution nmr | A | — | — |
| 2NB1 | P63/p73 hetero-tetramerisation domain | solution nmr | A, C | — | 5 (best 0.61) |
| 2NB1 | P63/P73 hetero-tetramerisation domain | solution nmr | A, C | — | — |
| 2RMN | The solution structure of the p63 DNA-binding domain | solution nmr | A | ZN | 1 (best 0.46) |
| 2RMN | The solution structure of the P63 DNA-binding domain | solution nmr | A | — | — |
| 2Y9T | Structural basis of p63a SAM domain mutants involved in AEC syndrome | solution nmr | A | — | — |
| 2Y9T | Structural basis of P63A SAM domain mutants involved in aec syndrome | solution nmr | A | — | — |
| 2Y9U | Structural basis of p63a SAM domain mutants involved in AEC syndrome | x-ray diffraction | A | SO4 | — |
| 2Y9U | Structural basis of P63A SAM domain mutants involved in aec syndrome | x-ray diffraction | A | — | — |
| 3QYM | Structure of p63 DNA Binding Domain in Complex with a 10 Base Pair A/T Rich Response Element Half… | x-ray diffraction | A, B, C, D, E, F, G, H | ZN | 20 (best 0.79) |
| 3QYM | Structure of P63 DNA binding domain in complex with a 10 base pair A/T rich response element half… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3QYN | Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair A/T Rich Response Element… | x-ray diffraction | A, B, C, D | ZN | 8 (best 0.77) |
| 3QYN | Structure of P63 DNA binding domain in complex with a 22 base pair A/T rich response element… | x-ray diffraction | A, B, C, D | — | — |
| 3US0 | Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair A/T Rich Response Element… | x-ray diffraction | A, B, C, D | ZN | 8 (best 0.77) |
| 3US0 | Structure of P63 DNA binding domain in complex with a 22 base pair A/T rich response element… | x-ray diffraction | A, B, C, D | — | — |
| 3US1 | Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair Response Element Containing a… | x-ray diffraction | A, D | ZN | 4 (best 0.35) |
| 3US1 | Structure of P63 DNA binding domain in complex with a 22 base pair response element containing a… | x-ray diffraction | A, D | — | — |
| 3US2 | Structure of p63 DNA Binding Domain in Complex with a 19 Base Pair A/T Rich Response Element… | x-ray diffraction | A, B, C, D, G, H, I, J | ZN | 20 (best 0.86) |
| 3US2 | Structure of P63 DNA binding domain in complex with a 19 base pair A/T rich response element… | x-ray diffraction | A, B, C, D, G, H, I, J | — | — |
| 3ZY0 | Crystal structure of a truncated variant of the human p63 tetramerization domain lacking the… | x-ray diffraction | A, B, C, D | — | — |
| 3ZY0 | Crystal structure of a truncated variant of the human P63 tetramerization domain lacking the… | x-ray diffraction | A, B, C, D | — | — |
| 3ZY1 | Crystal structure of the human p63 tetramerization domain | x-ray diffraction | A | — | — |
| 3ZY1 | Crystal structure of the human P63 tetramerization domain | x-ray diffraction | A | — | — |
| 4A9Z | Crystal structure of human P63 tetramerization domain | x-ray diffraction | A, B, C, D | — | 3 (best 0.39) |
| 4A9Z | Crystal structure of human P63 tetramerization domain | x-ray diffraction | A, B, C, D | — | — |
| 6FGN | Solution Structure of p300Taz2-p63TA | solution nmr | A | ZN | 3 (best 0.67) |
| 6FGN | Solution structure of P300TAZ2-P63TA | solution nmr | A | ZN | — |
| 6RU6 | Crystal structure of Casein Kinase I delta (CK1d) in complex with monophosphorylated p63 PAD1P… | x-ray diffraction | C | — | 1 (best 0.55) |
| 6RU6 | Crystal structure of casein kinase I delta (CK1D) in complex with monophosphorylated P63 PAD1P… | x-ray diffraction | C | — | — |
| 6RU7 | Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P… | x-ray diffraction | C, D | — | 3 (best 0.65) |
| 6RU7 | Crystal structure of casein kinase I delta (CK1D) in complex with double phosphorylated P63 PAD2P… | x-ray diffraction | C, D | — | — |
| 6RU8 | Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P… | x-ray diffraction | E, F, G, H | ADP | 9 (best 0.73) |
| 6RU8 | Crystal structure of casein kinase I delta (CK1D) in complex with triple phosphorylated P63 PAD3P… | x-ray diffraction | E, F, G, H | — | — |
| 7Z71 | Crystal structure of p63 DBD in complex with darpin C14 | x-ray diffraction | A, C | ZN | 7 (best 0.76) |
| 7Z71 | Crystal structure of P63 dbd in complex with darpin C14 | x-ray diffraction | A, C | ZN | — |
| 7Z72 | Crystal structure of p63 SAM in complex with darpin A5 | x-ray diffraction | A | — | 2 (best 0.40) |
| 7Z72 | Crystal structure of P63 SAM in complex with darpin A5 | x-ray diffraction | A | — | — |
| 7Z73 | Crystal structure of p63 tetramerization domain in complex with darpin 8F1 | x-ray diffraction | A, B, C, D | — | 3 (best 0.34) |
| 7Z73 | Crystal structure of P63 tetramerization domain in complex with darpin 8F1 | x-ray diffraction | A, B, C, D | — | — |
| 7Z7E | Crystal structure of p63 DNA binding domain in complex with inhibitory DARPin G4 | x-ray diffraction | A | ZN | 4 (best 0.59) |
| 7Z7E | Crystal structure of P63 DNA binding domain in complex with inhibitory darpin G4 | x-ray diffraction | A | ZN | — |
| 8P9C | Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11 | x-ray diffraction | A | — | 3 (best 0.45) |
| 8P9D | Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2 | x-ray diffraction | A, C | — | 6 (best 0.62) |
| 8P9E | Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with… | x-ray diffraction | A | — | 3 (best 0.48) |
| 9GFO | iASPP-CTD fusion to p63 peptide | x-ray diffraction | AAA, BBB, CCC, DDD | — | 6 (best 0.53) |
| Q9H3D4 | AlphaFold monomer V2.0 prediction for tumor protein 63 (Q9H3D4) | predicted | A | — | 3 (best 0.54) |
Ligands
Experiment against prediction
- 3US2 chain B against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.53 Å
- 3US2 chain B against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.53 Å
- 3US1 chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.53 Å
- 3US1 chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.53 Å
- 7Z71 chain C against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.57 Å
- 7Z71 chain C against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.57 Å
- 3QYN chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.62 Å
- 3QYN chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.62 Å
- 3US0 chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.63 Å
- 3US0 chain D against the predicted model Q9H3D4: TM-score 0.99, RMSD 0.63 Å
Elsewhere
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