MolNFT v1 · #45707 · protein
P63/P73 hetero-tetramerisation domain
2NB1 · Tumor protein 63: “P63/P73 hetero-tetramerisation domain”. Solution nmr, 5 pockets (best druggability 0.61). MolNFT v1 #45707 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2NB1
- Type
- protein
- Length
- 220 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor protein 63; Tumor protein P73
- UniProt
- Q9H3D4, O15350
- Pockets
- 5 · best druggability 0.61
Structure
solution nmr · 2 distinct chains · 59% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Tumor protein 63 | protein | 60 | 58% helix, 5% strand | Q9H3D4 |
| B, D | Tumor protein P73 | protein | 50 | 60% helix, 10% strand | O15350 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.61 | 0.83 | 19 | empty |
| 2 | 140 | 0.58 | 0.83 | 29 | empty |
| 3 | 152 | 0.57 | 0.82 | 19 | empty |
| 4 | 122 | 0.45 | 0.77 | 18 | empty |
| 5 | 135 | 0.43 | 0.75 | 21 | empty |
Interfaces
6 interfaces between chains.
- B–D · 1266 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1107 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 784 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 759 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 205 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2NB1 · P63/p73 hetero-tetramerisation domain · the same entry in another collection · chain A against A, TM-score 1.00
- O15350 · AlphaFold monomer V2.0 prediction for tumor protein P73 (O15350) · a predicted model of the same protein · chain B against A, TM-score 0.64
- Q9H3D4 · AlphaFold monomer V2.0 prediction for tumor protein 63 (Q9H3D4) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3D4
- Every structure of UniProt O15350
- Elsewhere: RCSB PDB 2NB1 · PDBe 2NB1 · UniProt Q9H3D4 · UniProt O15350
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