UniProt O15350
Tumor protein p73 (O15350)
Tumor protein p73 (UniProt O15350): 50 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15350
- Protein
- Tumor protein p73
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 46 · 5 records with a druggable one
Structures
51 records of O15350 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1COK | Structure of the C-terminal domain of P73 | solution nmr | A | — | — |
| 1COK | Structure of the C-terminal domain of P73 | solution nmr | A | — | — |
| 1DXS | Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha splice… | x-ray diffraction | A | — | — |
| 1DXS | Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human P73 alpha splice… | x-ray diffraction | A | — | — |
| 2KBY | The Tetramerization Domain of Human p73 | solution nmr | A, B, C, D | — | — |
| 2KBY | The tetramerization domain of human P73 | solution nmr | A, B, C, D | — | — |
| 2MPS | Structure of complex of MDM2(3-109) and P73 TAD(10-25) | solution nmr | B | — | — |
| 2MPS | Structure of complex of MDM2(3-109) and P73 TAD(10-25) | solution nmr | B | — | — |
| 2NB1 | P63/p73 hetero-tetramerisation domain | solution nmr | B, D | — | — |
| 2NB1 | P63/P73 hetero-tetramerisation domain | solution nmr | B, D | — | — |
| 2WQI | Crystal structure of the human p73 tetramerization domain | x-ray diffraction | A, B, C, D | — | — |
| 2WQI | Crystal structure of the human P73 tetramerization domain | x-ray diffraction | A, B, C, D | — | — |
| 2WQJ | Crystal structure of a truncated variant of the human p73 tetramerization domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 | — | — |
| 2WQJ | Crystal structure of a truncated variant of the human P73 tetramerization domain | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 | — | — |
| 2WTT | Structure of the human p73 tetramerization domain (crystal form II) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 2WTT | Structure of the human P73 tetramerization domain (crystal form II) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 2XWC | Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution | x-ray diffraction | A | — | — |
| 2XWC | Crystal structure of the DNA binding domain of human TP73 refined at 1.8 a resolution | x-ray diffraction | A | — | — |
| 3VD0 | structure of p73 DNA binding domain tetramer modulates p73 transactivation | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 3VD0 | Structure of P73 DNA binding domain tetramer modulates P73 transactivation | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 3VD1 | structure of p73 DNA binding domain tetramer modulates p73 transactivation | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 3VD1 | Structure of P73 DNA binding domain tetramer modulates P73 transactivation | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 3VD2 | structure of p73 DNA binding domain tetramer modulates p73 transactivation | x-ray diffraction | A, B, C, D, I, J | — | — |
| 3VD2 | Structure of P73 DNA binding domain tetramer modulates P73 transactivation | x-ray diffraction | A, B, C, D, I, J | — | — |
| 4A63 | Crystal structure of the p73-ASPP2 complex at 2.6A resolution | x-ray diffraction | A, C, E, G, I, K | — | — |
| 4A63 | Crystal structure of the P73-ASPP2 complex at 2.6A resolution | x-ray diffraction | A, C, E, G, I, K | — | — |
| 4G82 | Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element | x-ray diffraction | A, B | — | — |
| 4G82 | Crystal structure of P73 DNA-binding domain tetramer bound to a full response-element | x-ray diffraction | A, B | — | — |
| 4G83 | Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element | x-ray diffraction | A, B | — | — |
| 4G83 | Crystal structure of P73 DNA-binding domain tetramer bound to a full response-element | x-ray diffraction | A, B | — | — |
| 4GUO | structure of p73 DNA binding domain complex with 12 bp DNA | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 4GUO | Structure of P73 DNA binding domain complex with 12 bp DNA | x-ray diffraction | A, B, C, D, I, J, K, L | — | — |
| 4GUQ | Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element | x-ray diffraction | A, B | — | — |
| 4GUQ | Structure of MUTS139F P73 DNA binding domain complexed with 20BP DNA response element | x-ray diffraction | A, B | — | — |
| 5HOB | p73 homo-tetramerization domain mutant I | x-ray diffraction | A, B, C, D, E, F, G, H | MG | — |
| 5HOB | P73 homo-tetramerization domain mutant I | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5HOC | p73 homo-tetramerization domain mutant II | x-ray diffraction | A, B | — | — |
| 5HOC | P73 homo-tetramerization domain mutant II | x-ray diffraction | A, B | — | — |
| 5KBD | Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response… | x-ray diffraction | A, B | ZN | 9 (best 0.70) |
| 5KBD | Structural studies of transcription factor P73 DNA binding domain bound to PA26 20-mer response… | x-ray diffraction | A, B | ZN | — |
| 6FGS | Solution structure of p300Taz2-p73TA1 | solution nmr | A | ZN | — |
| 6FGS | Solution structure of P300TAZ2-P73TA1 | solution nmr | A | ZN | — |
| 6IJQ | Solution structure of BCL-XL bound to P73-TAD peptide | solution nmr | A | — | 2 (best 0.52) |
| 6IJQ | Solution structure of BCL-xl bound to P73-tad peptide | solution nmr | A | — | — |
| 7EZJ | Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response… | x-ray diffraction | A, B, C, D, I, J, K, L, a, b, c, d, i, j, k, l | ZN | 20 (best 0.81) |
| 7EZJ | Crystal structure of P73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response… | x-ray diffraction | A, B, C, D, I, J, K, L, a, b, c, d, i, j, k, l | ZN | — |
| 8P9C | Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 F11 | x-ray diffraction | B | — | 3 (best 0.45) |
| 8P9D | Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with darpin 1810 A2 | x-ray diffraction | B, D | — | 6 (best 0.62) |
| 8P9E | Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in complex with… | x-ray diffraction | B | — | 3 (best 0.48) |
| 9GNB | Structure of p73 SAM domain in complex with DARPin B9 | x-ray diffraction | A | — | 1 (best 0.28) |
| O15350 | AlphaFold monomer V2.0 prediction for tumor protein P73 (O15350) | predicted | A | — | 2 (best 0.56) |
Ligands
Experiment against prediction
- 7EZJ chain D against the predicted model O15350: TM-score 0.99, RMSD 0.68 Å
- 3VD0 chain I against the predicted model O15350: TM-score 0.98, RMSD 0.73 Å
- 7EZJ chain c against the predicted model O15350: TM-score 0.98, RMSD 0.75 Å
- 3VD1 chain B against the predicted model O15350: TM-score 0.98, RMSD 0.74 Å
- 4GUO chain B against the predicted model O15350: TM-score 0.98, RMSD 0.75 Å
- 7EZJ chain d against the predicted model O15350: TM-score 0.98, RMSD 0.87 Å
- 3VD0 chain D against the predicted model O15350: TM-score 0.98, RMSD 0.75 Å
- 7EZJ chain A against the predicted model O15350: TM-score 0.98, RMSD 0.79 Å
- 4GUO chain A against the predicted model O15350: TM-score 0.98, RMSD 0.78 Å
- 4GUO chain I against the predicted model O15350: TM-score 0.98, RMSD 0.79 Å
Elsewhere
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