MolNFT v1 · #152505 · protein
Solution structure of BCL-xl bound to P73-tad peptide
6IJQ · Tumor protein P73: “Solution structure of BCL-xl bound to P73-tad peptide”. Solution nmr, 5 pockets (best druggability 0.55). MolNFT v1 #152505 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6IJQ
- Type
- protein
- Length
- 187 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor protein P73; BCL-2-like protein 1,BCL-2-like protein 1
- UniProt
- O15350, Q07817
- Pockets
- 5 · best druggability 0.55
Structure
solution nmr · 2 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor protein P73 | protein | 16 | 50% helix, 0% strand | O15350 |
| B | BCL-2-like protein 1,BCL-2-like protein 1 | protein | 171 | 67% helix, 0% strand | Q07817 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.55 | 0.89 | 12 | empty |
| 2 | 118 | 0.52 | 0.81 | 22 | empty |
| 3 | 54 | 0.40 | 0.81 | 17 | empty |
| 4 | 66 | 0.37 | 0.78 | 19 | empty |
| 5 | 56 | 0.29 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 478 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15350
- Every structure of UniProt Q07817
- Elsewhere: RCSB PDB 6IJQ · PDBe 6IJQ · UniProt O15350 · UniProt Q07817
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