MolNFT v1 · #148776 · protein
Solution structure of P300TAZ2-P63TA
6FGN · Histone acetyltransferase P300,TUMOR protein 63: “Solution structure of P300TAZ2-P63TA”. Solution nmr, 1 ligand (ZN), 3 pockets (best druggability 0.67). MolNFT v1 #148776 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6FGN
- Type
- protein
- Length
- 124 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase P300,TUMOR protein 63
- EC
- 2.3.1.48, 2.3.1.-
- UniProt
- Q09472, Q9H3D4
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.67
Structure
solution nmr · 1 distinct chain · 51% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase P300,TUMOR protein 63 (EC 2.3.1.48, 2.3.1.-) | protein | 124 | 51% helix, 0% strand | Q09472, Q9H3D4 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.67 | 0.90 | 21 | empty |
| 2 | 108 | 0.42 | 0.77 | 17 | empty |
| 3 | 94 | 0.40 | 0.77 | 15 | empty |
Compared structures
- 6FGN · Solution Structure of p300Taz2-p63TA · the same entry in another collection · chain A against A, TM-score 1.00
- Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain A against A, TM-score 0.60
- Q9H3D4 · AlphaFold monomer V2.0 prediction for tumor protein 63 (Q9H3D4) · a predicted model of the same protein · chain A against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09472
- Every structure of UniProt Q9H3D4
- Elsewhere: RCSB PDB 6FGN · PDBe 6FGN · UniProt Q09472 · UniProt Q9H3D4
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