UniProt Q9H2K2
Poly [ADP-ribose] polymerase tankyrase-2 (Q9H2K2)
Poly [ADP-ribose] polymerase tankyrase-2 (UniProt Q9H2K2), EC 2.4.2.-, 2.4.2.30: 323 experimental structures on GenesisL1, 37 ligands bound, 51 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9H2K2
- Protein
- Poly [ADP-ribose] polymerase tankyrase-2
- EC
- 2.4.2.-, 2.4.2.30
- Experimental structures
- 323
- Predicted models
- 0
- Ligands
- 37
- Pockets
- 51 · 12 records with a druggable one
Structures
323 records of Q9H2K2 in the MolNFT archive: 323 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Y0I | Factor inhibiting hif-1 alpha in complex with tankyrase-2 (TNKS2) fragment peptide (21-mer) | x-ray diffraction | S | — | — |
| 2Y0I | Factor inhibiting hif-1 alpha in complex with tankyrase-2 (TNKS2) fragment peptide (21-mer) | x-ray diffraction | S | — | — |
| 3KR7 | Human tankyrase 2 - catalytic PARP domain | x-ray diffraction | A | — | — |
| 3KR7 | Human tankyrase 2 - catalytic parp domain | x-ray diffraction | A | — | — |
| 3KR8 | Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939 | x-ray diffraction | A, C | — | — |
| 3KR8 | Human tankyrase 2 - catalytic parp domain in complex with an inhibitor XAV939 | x-ray diffraction | A, C | — | — |
| 3MHJ | Human tankyrase 2 - catalytic PARP domain in complex with… | x-ray diffraction | A, B | — | — |
| 3MHJ | Human tankyrase 2 - catalytic parp domain in complex with 1-methyl-3… | x-ray diffraction | A, B | — | — |
| 3MHK | Human tankyrase 2 - catalytic PARP domain in complex with… | x-ray diffraction | A | — | — |
| 3MHK | Human tankyrase 2 - catalytic parp domain in complex with 2-(2… | x-ray diffraction | A | — | — |
| 3P0N | Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3P0N | Human tankyrase 2 - catalytic parp domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3P0P | Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3P0P | Human tankyrase 2 - catalytic parp domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3P0Q | Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3P0Q | Human tankyrase 2 - catalytic parp domain in complex with an inhibitor | x-ray diffraction | A, C | — | — |
| 3TWQ | Crystal structure of ARC4 from human Tankyrase 2 (apo form) | x-ray diffraction | A, B | — | — |
| 3TWQ | Crystal structure of ARC4 from human tankyrase 2 (apo form) | x-ray diffraction | A, B | — | — |
| 3TWR | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human 3BP2 | x-ray diffraction | A, B, C, D | — | — |
| 3TWR | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human 3BP2 | x-ray diffraction | A, B, C, D | — | — |
| 3TWS | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human TERF1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWS | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human TERF1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWT | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human MCL1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWT | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human MCL1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWU | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human MCL1 | x-ray diffraction | A | — | — |
| 3TWU | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human MCL1 | x-ray diffraction | A | — | — |
| 3TWV | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human NUMA1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWV | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human NUMA1 (chimeric… | x-ray diffraction | A, B, C, D | — | — |
| 3TWW | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human LNPEP (chimeric… | x-ray diffraction | A, B | — | — |
| 3TWW | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human lnpep (chimeric… | x-ray diffraction | A, B | — | — |
| 3TWX | Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human FNBP1 (chimeric… | x-ray diffraction | A, B | — | — |
| 3TWX | Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human FNBP1 (chimeric… | x-ray diffraction | A, B | — | — |
| 3U9H | Complex structure of human tankyrase 2 with nicotinamide | x-ray diffraction | A, B | — | — |
| 3U9H | Complex structure of human tankyrase 2 with nicotinamide | x-ray diffraction | A, B | — | — |
| 3U9Y | Crystal structure of human tankyrase 2 catalytic domain in complex with olaparib | x-ray diffraction | A | — | — |
| 3U9Y | Crystal structure of human tankyrase 2 catalytic domain in complex with olaparib | x-ray diffraction | A | — | — |
| 3UA9 | Crystal structure of human tankyrase 2 in complex with a selective inhibitor | x-ray diffraction | A, B | — | — |
| 3UA9 | Crystal structure of human tankyrase 2 in complex with a selective inhibitor | x-ray diffraction | A, B | — | — |
| 3W51 | Tankyrase in complex with 2-hydroxy-4-methylquinoline | x-ray diffraction | A, B | — | — |
| 3W51 | Tankyrase in complex with 2-hydroxy-4-methylquinoline | x-ray diffraction | A, B | — | — |
| 4AVU | Crystal structure of human tankyrase 2 in complex with 6(5H)- phenanthridi | x-ray diffraction | A, B | — | — |
| 4AVU | Crystal structure of human tankyrase 2 in complex with 6(5H)- phenanthridinone | x-ray diffraction | A, B | — | — |
| 4AVW | Crystal structure of human tankyrase 2 in complex with TIQ-A | x-ray diffraction | A, B | — | — |
| 4AVW | Crystal structure of human tankyrase 2 in complex with tiq-a | x-ray diffraction | A, B | — | — |
| 4BFP | Crystal structure of human tankyrase 2 in complex with WIKI4 | x-ray diffraction | A, B | — | — |
| 4BFP | Crystal structure of human tankyrase 2 in complex with WIKI4 | x-ray diffraction | A, B | — | — |
| 4BJ9 | Crystal structure of human tankyrase 2 in complex with EB-47 | x-ray diffraction | A, B | — | — |
| 4BJ9 | Crystal structure of human tankyrase 2 in complex with eb-47 | x-ray diffraction | A, B | — | — |
| 4BJB | Crystal structure of human tankyrase 2 in complex with PJ-34 | x-ray diffraction | A | — | — |
| 4BJB | Crystal structure of human tankyrase 2 in complex with pj-34 | x-ray diffraction | A | — | — |
| 4BJC | Crystal structure of human tankyrase 2 in complex with Rucaparib | x-ray diffraction | A | — | — |
| 4BJC | Crystal structure of human tankyrase 2 in complex with rucaparib | x-ray diffraction | A | — | — |
| 4BS4 | Crystal structure of human tankyrase 2 in complex with 4'-isopropylflavone | x-ray diffraction | A, B | — | — |
| 4BS4 | Crystal structure of human tankyrase 2 in complex with 4'- isopropylflavone | x-ray diffraction | A, B | — | — |
| 4BU3 | Crystal structure of human tankyrase 2 in complex with 2-phenyl-3,4- dihydroquinazolin-4-one | x-ray diffraction | A, B | — | — |
| 4BU3 | Crystal structure of human tankyrase 2 in complex with 2-phenyl-3,4- dihydroquinazolin-4-one | x-ray diffraction | A, B | — | — |
| 4BU5 | Crystal structure of human tankyrase 2 in complex with 2-(4… | x-ray diffraction | A, B | — | — |
| 4BU5 | Crystal structure of human tankyrase 2 in complex with 2-(4… | x-ray diffraction | A, B | — | — |
| 4BU6 | Crystal structure of human tankyrase 2 in complex with 2-(4… | x-ray diffraction | A, B | — | — |
| 4BU6 | Crystal structure of human tankyrase 2 in complex with 2-(4… | x-ray diffraction | A, B | — | — |
263 records more on the page itself.
Ligands
- ZN · Zinc ion · in 48 records
- SO4 · Sulfate ion · in 36 records
- PO4 · Phosphate ion · in 8 records
- 97H · 2-(3-aminophenyl)-3~{H}-quinazolin-4-one · in 2 records
- 97K · 2-(2~{H}-indazol-5-yl)-3~{H}-quinazolin-4-one · in 2 records
- 97Z · 2-[4-morpholin-4-yl]-3,4-dihydroquinazolin-4-one · in 2 records
- 9AN · 2-(3-hydroxyphenyl)-3~{H}-quinazolin-4-one · in 2 records
- 9AQ · 2-(4-ethoxyphenyl)-3~{H}-quinazolin-4-one · in 2 records
- 9AW · 2-(4-pyridin-2-ylphenyl)-3~{H}-quinazolin-4-one · in 2 records
- 9B2 · 2-(4-piperidin-1-ylphenyl)-3~{H}-quinazolin-4-one · in 2 records
- 9CB · 7-chloranyl-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one · in 2 records
- 9CE · 2-(2-aminophenyl)-3~{H}-quinazolin-4-one · in 2 records
- 9D5 · 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-2,3-dihydro-1~{H}-quinazolin-4-one · in 2 records
- 9SU · 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one · in 2 records
- DU9 · 6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-fluoranyl-1-methyl-1'-(8-methyl-4-oxidanylidene-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-2-yl)spiro[indole-3, 4'-piperidine]-2-one · in 2 records
- KC8 · 2-[4-[(4~{S})-4-methyl-2-oxidanylidene-imidazolidin-4-yl]phenyl]-3~{H}-quinazolin-4-one · in 2 records
- VJN · 8-propan-2-yloxy-4~{H}-thieno[2,3-c]isoquinolin-5-one · in 2 records
- 0E1 · (7R)-2-hydroxy-7-(propan-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile · in 1 record
- 59B · morpholin-4-yl[4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)phenyl]methanone · in 1 record
- 5ZI · 4-[3-(4-oxo-3,4-dihydroquinazolin-2- yl)propanamido]-N-(quinolin-8-yl)benzamide · in 1 record
- 92T · 1-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile · in 1 record
- 97E · 1-[4-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile · in 1 record
- 9A8 · 2-(4-propan-2-yloxyphenyl)-3~{H}-quinazolin-4-one · in 1 record
- 9C5 · 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one · in 1 record
- 9C8 · 2-[4-(diethylamino)phenyl]-3~{H}-quinazolin-4-one · in 1 record
- 9GX · 2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one · in 1 record
- 9H3 · 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one · in 1 record
- 9H6 · 1-methyl-1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)spiro[indole-3,4'-piperidin]-2(1H)-one · in 1 record
- 9H9 · 2-[4,6-difluoro-1-(2-hydroxyethyl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one · in 1 record
- BCT · Bicarbonate ion · in 1 record
Elsewhere
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