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Ligand · NNF

NNF · 2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one

NNF, 2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one (C15 H17 F N4 O, 288.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å, the residues…

Component
NNF
Formula
C15 H17 F N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

NNF in 2 structures; the first of them:

  • 3P0P · Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor · NNF A1163 · binds PHE1030, HIS1031, GLY1032, SER1033, PHE1035, ARG1047, HIS1048, ALA1049 and 9 more
  • 3P0P · Human tankyrase 2 - catalytic parp domain in complex with an inhibitor · NNF A1163 · binds PHE1030, HIS1031, GLY1032, SER1033, PHE1035, ARG1047, HIS1048, ALA1049 and 9 more

Residues it binds most

PHE 4, TYR 4, ALA 4, HIS 4, SER 4, GLU 4, GLY 4, ILE 4, LYS 4, ARG 2 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SO4 · Sulfate ion

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