UniProt Q9H237
Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine (Q9H237)
Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine (UniProt Q9H237), EC 2.3.1.250: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 29 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9H237
- Protein
- Isoform 2 of Protein-serine O-palmitoleoyltransferase porcupine
- EC
- 2.3.1.250
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 29 · 5 records with a druggable one
Structures
9 records of Q9H237 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7URA | Human PORCN in complex with Palmitoleoyl-CoA | electron microscopy | A | OH6, ZN, CLR, AJP, OLA | 5 (best 0.78) |
| 7URA | Human porcn in complex with palmitoleoyl-CoA | electron microscopy | A | OH6, ZN, CLR, AJP, OLA | — |
| 7URC | Human PORCN in complex with LGK974 | electron microscopy | A | O50, CLR, AJP, ZN | 5 (best 0.77) |
| 7URC | Human porcn in complex with LGK974 | electron microscopy | A | O50, CLR, AJP, ZN | — |
| 7URD | Human PORCN in complex with LGK974 and WNT3A peptide | electron microscopy | A | O50, CLR, AJP, OLA, ZN | 5 (best 0.80) |
| 7URD | Human porcn in complex with LGK974 and WNT3A peptide | electron microscopy | A | O50, CLR, AJP, OLA, ZN | — |
| 7URE | Human PORCN in complex with palmitoleoylated WNT3A peptide | electron microscopy | A | AJP, ZN, PAM | 6 (best 0.78) |
| 7URE | Human porcn in complex with palmitoleoylated WNT3A peptide | electron microscopy | A | AJP, ZN, PAM | — |
| Q9H237 | AlphaFold monomer V2.0 prediction for protein-serine O-palmitoleoyltransferase porcupine (Q9H237) | predicted | A | — | 8 (best 0.81) |
Ligands
- AJP · Digitonin · in 8 records
- ZN · Zinc ion · in 8 records
- CLR · Cholesterol · in 6 records
- O50 · 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide · in 4 records
- OLA · Oleic acid · in 4 records
- OH6 · ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{Z})-hexadec-9-enethioate · in 2 records
- PAM · Palmitoleic acid · in 2 records
Experiment against prediction
- 7URE chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.06 Å
- 7URE chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.06 Å
- 7URD chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.12 Å
- 7URD chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.12 Å
- 7URA chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.13 Å
- 7URA chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.13 Å
- 7URC chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.16 Å
- 7URC chain A against the predicted model Q9H237: TM-score 0.98, RMSD 1.16 Å
Elsewhere
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