MolNFT v1 · #305222 · protein
AlphaFold monomer V2.0 prediction for protein-serine O-palmitoleoyltransferase porcupine (Q9H237)
Q9H237: “AlphaFold monomer V2.0 prediction for protein-serine O-palmitoleoyltransferase porcupine (Q9H237)”. 8 pockets (best druggability 0.81). MolNFT v1 #305222 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9H237
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71112d4fF7ebb3b617963c05f052289e073082FD
- Molecule
- Protein-serine O-palmitoleoyltransferase porcupine
- UniProt
- Q9H237
- Pockets
- 8 · best druggability 0.81
Structure
1 distinct chain · 75% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-serine O-palmitoleoyltransferase porcupine | protein | 461 | 75% helix, 2% strand | Q9H237 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 999 | 0.81 | 0.82 | 76 | empty |
| 2 | 174 | 0.56 | 0.80 | 21 | empty |
| 3 | 148 | 0.44 | 0.75 | 21 | empty |
| 4 | 98 | 0.43 | 0.78 | 20 | empty |
| 5 | 53 | 0.37 | 0.79 | 13 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7URE · Human porcn in complex with palmitoleoylated WNT3A peptide · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URE · Human PORCN in complex with palmitoleoylated WNT3A peptide · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URD · Human PORCN in complex with LGK974 and WNT3A peptide · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URD · Human porcn in complex with LGK974 and WNT3A peptide · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URA · Human porcn in complex with palmitoleoyl-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URA · Human PORCN in complex with Palmitoleoyl-CoA · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URC · Human PORCN in complex with LGK974 · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7URC · Human porcn in complex with LGK974 · an experimental structure of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H237
- Elsewhere: UniProt Q9H237 · AlphaFold DB Q9H237
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