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Ligand · O50

O50 · 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide

O50, 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (C23 H20 N6 O, 396.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues…

Component
O50
Formula
C23 H20 N6 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

O50 in 4 structures; the first of them:

  • 7URC · Human PORCN in complex with LGK974 · O50 A501 · binds PHE246, HIS247, VAL296, VAL297, TRP300, MET304, SER305, LEU308 and 15 more
  • 7URD · Human PORCN in complex with LGK974 and WNT3A peptide · O50 A501 · binds PHE246, HIS247, VAL296, VAL297, TRP300, MET304, SER305, LEU308 and 15 more
  • 7URC · Human porcn in complex with LGK974 · O50 A501 · binds VAL297, TRP300, MET304, SER305, LEU308, ASN309, PHE313, VAL325 and 11 more
  • 7URD · Human porcn in complex with LGK974 and WNT3A peptide · O50 A501 · binds VAL297, TRP300, SER305, LEU308, ASN309, PHE313, THR328, TYR329 and 10 more

Residues it binds most

LEU 4, VAL 4, PHE 4, SER 4, HIS 4, ASN 4, GLY 4, THR 4, TRP 4, TYR 4 (residue and the binding sites it lines).

Found with

  • AJP · Digitonin
  • CLR · Cholesterol
  • ZN · Zinc ion
  • OLA · Oleic acid

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