UniProt Q9GZV9
Fibroblast growth factor 23 (Q9GZV9)
Fibroblast growth factor 23 (UniProt Q9GZV9): 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9GZV9
- Protein
- Fibroblast growth factor 23
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 33 · 4 records with a druggable one
Structures
10 records of Q9GZV9 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2P39 | Crystal structure of human FGF23 | x-ray diffraction | A | — | — |
| 2P39 | Crystal structure of human FGF23 | x-ray diffraction | A | — | — |
| 5W21 | Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex | x-ray diffraction | B | — | — |
| 5W21 | Crystal structure of a 1:1:1 FGF23-FGFR1C-aklotho ternary complex | x-ray diffraction | B | — | — |
| 6S22 | Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c | x-ray diffraction | F | UDP, NGA | 3 (best 0.75) |
| 6S22 | Crystal structure of the tggalnac-T3 in complex with udp, manganese and FGF23C | x-ray diffraction | F | UDP, NGA | — |
| 7YSH | Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | electron microscopy | B | SGN, IDS | 8 (best 0.81) |
| 7YSU | Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | electron microscopy | B | IDS, SGN | 11 (best 0.75) |
| 7YSW | Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | electron microscopy | B | IDS, SGN | 11 (best 0.75) |
| Q9GZV9 | AlphaFold monomer V2.0 prediction for fibroblast growth factor 23 (Q9GZV9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5W21 chain B against the predicted model Q9GZV9: TM-score 0.94, RMSD 1.51 Å
- 5W21 chain B against the predicted model Q9GZV9: TM-score 0.94, RMSD 1.51 Å
- 2P39 chain A against the predicted model Q9GZV9: TM-score 0.93, RMSD 1.50 Å
- 2P39 chain A against the predicted model Q9GZV9: TM-score 0.93, RMSD 1.50 Å
- 7YSU chain B against the predicted model Q9GZV9: TM-score 0.87, RMSD 2.34 Å
- 7YSH chain B against the predicted model Q9GZV9: TM-score 0.86, RMSD 2.26 Å
- 7YSW chain B against the predicted model Q9GZV9: TM-score 0.85, RMSD 2.25 Å
- 6S22 chain F against the predicted model Q9GZV9: TM-score 0.29, RMSD 2.09 Å
- 6S22 chain F against the predicted model Q9GZV9: TM-score 0.29, RMSD 2.09 Å
Elsewhere
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