UniProt Q9FVQ6
Pinoresinol reductase 1 (Q9FVQ6)
Pinoresinol reductase 1 (UniProt Q9FVQ6), EC 1.23.1.1, 1.23.1.3: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 94 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9FVQ6
- Protein
- Pinoresinol reductase 1
- EC
- 1.23.1.1, 1.23.1.3
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 94 · 8 records with a druggable one
Structures
15 records of Q9FVQ6 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7CS9 | AtPrR1 in apo form | x-ray diffraction | B, C, A, D | — | 16 (best 0.69) |
| 7CS9 | ATPRR1 in apo form | x-ray diffraction | B, C, A, D | — | — |
| 7CSA | AtPrR1 with NADP+ | x-ray diffraction | A, B, C, D | NDP | 10 (best 0.77) |
| 7CSA | ATPRR1 with NADP+ | — | — | — | |
| 7CSB | AtPrR1 with NADP+ and (+)pinoresinol | x-ray diffraction | C, D, A, B | GEC, NDP | 12 (best 0.83) |
| 7CSB | ATPRR1 with NADP+ and (+)pinoresinol | x-ray diffraction | C, D, A, B | GEC, NDP | — |
| 7CSC | AtPrR1 with NADP+ and (-)pinoresinol | x-ray diffraction | E, F, A, B, C, D | GEF, NDP | 15 (best 0.84) |
| 7CSC | ATPRR1 with NADP+ and (-)pinoresinol | x-ray diffraction | E, F, A, B, C, D | GEF, NDP | — |
| 7CSD | AtPrR1 with NADP+ and (+)lariciresinol | x-ray diffraction | C, D, A, B | GFU, NDP | 13 (best 0.84) |
| 7CSD | ATPRR1 with NADP+ and (+)lariciresinol | x-ray diffraction | C, D, A, B | GFU, NDP | — |
| 7CSE | AtPrR1 with NADP+ and (-)lariciresinol | x-ray diffraction | E, F, A, B, C, D | GFR, NDP | 18 (best 0.83) |
| 7CSE | ATPRR1 with NADP+ and (-)lariciresinol | x-ray diffraction | E, F, A, B, C, D | GFR, NDP | — |
| 7CSF | AtPrR1 with NADP+ and (-)secoisolariciresinol | x-ray diffraction | C, D, A, B | GO6, NDP | 9 (best 0.82) |
| 7CSF | ATPRR1 with NADP+ and (-)secoisolariciresinol | x-ray diffraction | C, D, A, B | GO6, NDP | — |
| Q9FVQ6 | AlphaFold monomer V2.0 prediction for pinoresinol reductase 1 (Q9FVQ6) | predicted | A | — | 1 (best 0.81) |
Ligands
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 11 records
- GEC · 4-[(3s,3ar,6s,6ar)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3, 3A,4,6,6A-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol · in 2 records
- GEF · 4-[(3r,3as,6r,6as)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3, 3A,4,6,6A-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol · in 2 records
- GFR · 4-[[(3S,4S,5R)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol · in 2 records
- GFU · 4-[[(3R,4R,5S)-4-(hydroxymethyl)-5-(3-methoxy-4-oxidanyl-phenyl)oxolan-3-yl]methyl]-2-methoxy-phenol · in 2 records
- GO6 · (2R,3R)-2,3-bis[(3-methoxy-4-oxidanyl-phenyl) methyl]butane-1,4-diol · in 2 records
Experiment against prediction
- 7CSE chain E against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.80 Å
- 7CSE chain E against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.80 Å
- 7CSC chain E against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSC chain E against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSC chain A against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSE chain B against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSE chain C against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSE chain C against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSE chain F against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.81 Å
- 7CSF chain B against the predicted model Q9FVQ6: TM-score 0.99, RMSD 0.83 Å
Elsewhere
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