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Ligand · GEF

GEF · 4-[(3r,3as,6r,6as)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3, 3A,4,6,6A-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol

GEF, 4-[(3r,3as,6r,6as)-6-(3-methoxy-4-oxidanyl-phenyl)-1,3, 3A,4,6,6A-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxy-phenol (C20 H22 O6, 358.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding…

Component
GEF
Formula
C20 H22 O6
Class
ligand
Structures
4
PDB entries
2

Binding sites

GEF in 4 structures; the first of them:

  • 7CS5 · IiPLR1 with NADP+ and (-)pinoresinol · GEF E401 · binds GLY124, MET125, ALA164, TYR169, PHE170, ASN173, GLN176, MET177 and 7 more
  • 7CSC · AtPrR1 with NADP+ and (-)pinoresinol · GEF E401 · binds VAL92, PHE94, GLY124, MET125, PHE141, ALA164, CYS165, TYR169 and 12 more
  • 7CS5 · IIPLR1 with NADP+ and (-)pinoresinol · GEF E401 · binds GLY124, MET125, ALA164, TYR169, PHE170, ASN173, GLN176, MET177 and 7 more
  • 7CSC · ATPRR1 with NADP+ and (-)pinoresinol · GEF E401 · binds PHE94, GLY124, MET125, CYS165, TYR169, PHE170, ASN173, MET177 and 5 more

Residues it binds most

PHE 24, GLY 24, MET 24, HIS 24, THR 24, GLN 23, LEU 23, VAL 19, ASN 24, ILE 24 (residue and the binding sites it lines).

Found with

  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate

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