UniProt Q9BYC5
Alpha-(1,6)-fucosyltransferase (Q9BYC5)
Alpha-(1,6)-fucosyltransferase (UniProt Q9BYC5), EC 2.4.1.68: 14 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9BYC5
- Protein
- Alpha-(1,6)-fucosyltransferase
- EC
- 2.4.1.68
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 48 · 3 records with a druggable one
Structures
15 records of Q9BYC5 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DE0 | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 | x-ray diffraction | X | — | — |
| 2DE0 | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 | x-ray diffraction | X | — | — |
| 6TKV | Crystal structure of the human FUT8 in complex with GDP and a biantennary complex N-glycan | x-ray diffraction | A, B | NAG, BMA, MAN, GDP | 8 (best 0.70) |
| 6TKV | Crystal structure of the human FUT8 in complex with GDP and a biantennary complex N-glycan | x-ray diffraction | A, B | NAG, BMA, MAN, GDP | — |
| 6VLD | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 bound to GDP and A2SGP | x-ray diffraction | A, B, G, H | NAG, BMA, MAN, GDP, SO4 | — |
| 6VLE | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 in its Apo-form | x-ray diffraction | A, B | SO4 | — |
| 6VLE | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 in its apo-form | x-ray diffraction | A, B | SO4 | — |
| 6X5H | Human alpha-1,6-fucosyltransferase (FUT8) bound to GDP | x-ray diffraction | A, B, C, D | GDP | — |
| 6X5R | Human alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A2-asn | x-ray diffraction | A, B | NAG, BMA, MAN, MN, GDP | — |
| 6X5S | Human alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3'-asn | x-ray diffraction | A, B | NAG, BMA, MAN, CL, GDP | — |
| 6X5T | Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3-Asn | x-ray diffraction | A, B, C, D, E, F, G, H | NAG, BMA, MAN, GDP | 20 (best 0.86) |
| 6X5T | Human alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3-asn | x-ray diffraction | A, B, C, D, E, F, G, H | NAG, BMA, MAN, GDP | — |
| 6X5U | Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and NM5M2-Asn | x-ray diffraction | A, B, C, D, E, F, G, H | NAG, BMA, MAN, GDP, ASN | 20 (best 0.85) |
| 6X5U | Human alpha-1,6-fucosyltransferase (FUT8) bound to GDP and NM5M2-asn | x-ray diffraction | A, B, C, D, E, F, G, H | NAG, BMA, MAN, GDP | — |
| Q9BYC5 | AlphaFold monomer V2.0 prediction for alpha-(1,6)-fucosyltransferase (Q9BYC5) | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 10 records
- BMA · beta-D-mannopyranose · in 9 records
- MAN · alpha-D-mannopyranose · in 9 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 9 records
- SO4 · Sulfate ion · in 3 records
- ASN · Asparagine · in 1 record
- CL · Chloride ion · in 1 record
- MN · Manganese (II) ion · in 1 record
Experiment against prediction
- 6X5R chain A against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.25 Å
- 6X5H chain C against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.25 Å
- 6X5T chain A against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.26 Å
- 6X5T chain A against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.26 Å
- 6X5T chain C against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
- 6X5T chain C against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
- 6X5T chain B against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
- 6X5T chain B against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
- 6X5T chain G against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
- 6X5T chain G against the predicted model Q9BYC5: TM-score 1.00, RMSD 0.27 Å
Elsewhere
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