UniProt Q9BVS4
Serine/threonine-protein kinase RIO2 (Q9BVS4)
Serine/threonine-protein kinase RIO2 (UniProt Q9BVS4), EC 2.7.11.1: 15 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9BVS4
- Protein
- Serine/threonine-protein kinase RIO2
- EC
- 2.7.11.1
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 50 · 7 records with a druggable one
Structures
16 records of Q9BVS4 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6FDM | Human Rio2 kinase structure | x-ray diffraction | A, B, C, D | ANP, NA | — |
| 6FDM | Human RIO2 kinase structure | x-ray diffraction | A, B, C, D | ANP, NA | — |
| 6FDN | Rio2 structure | x-ray diffraction | A, B | — | 9 (best 0.74) |
| 6FDN | RIO2 structure | x-ray diffraction | A, B | — | — |
| 6FDO | Rio2 structure | x-ray diffraction | A, B | — | 6 (best 0.81) |
| 6FDO | RIO2 structure | x-ray diffraction | A, B | — | — |
| 6G18 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State C | electron microscopy | v | — | 1 (best 0.84) |
| 6G18 | Cryo-EM structure of a late human pre-40S ribosomal subunit - state C | electron microscopy | v | — | — |
| 6G51 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State D | electron microscopy | v | — | 2 (best 0.77) |
| 6G51 | Cryo-EM structure of a late human pre-40S ribosomal subunit - state D | electron microscopy | v | — | — |
| 6HK6 | Human RIOK2 bound to inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | G8H, CL | 20 (best 0.88) |
| 6HK6 | Human RIOK2 bound to inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | G8H, CL | — |
| 7VBT | Crystal structure of RIOK2 in complex with CQ211 | x-ray diffraction | A, B | 5ZH | 7 (best 0.80) |
| 7VBT | Crystal structure of RIOK2 in complex with CQ211 | x-ray diffraction | A, B | 5ZH | — |
| 7WU0 | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B3 | electron microscopy | v | — | — |
| Q9BVS4 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase RIO2 (Q9BVS4) | predicted | A | — | 5 (best 0.78) |
Ligands
- 5ZH · 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- CL · Chloride ion · in 2 records
- G8H · 2-naphthalen-2-yl-~{N}-pyridin-2-yl-ethanamide · in 2 records
- NA · Sodium ion · in 2 records
Experiment against prediction
- 6HK6 chain G against the predicted model Q9BVS4: TM-score 0.96, RMSD 1.53 Å
- 6HK6 chain G against the predicted model Q9BVS4: TM-score 0.96, RMSD 1.53 Å
- 6FDN chain B against the predicted model Q9BVS4: TM-score 0.96, RMSD 1.27 Å
- 6FDN chain B against the predicted model Q9BVS4: TM-score 0.96, RMSD 1.27 Å
- 6FDN chain A against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.30 Å
- 6FDN chain A against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.30 Å
- 6FDM chain B against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.78 Å
- 6FDM chain B against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.78 Å
- 6HK6 chain H against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.69 Å
- 6HK6 chain H against the predicted model Q9BVS4: TM-score 0.95, RMSD 1.69 Å
Elsewhere
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