MolNFT v1 · #148680 · protein

RIO2 structure

6FDN · SERINE/THREONINE-protein kinase RIO2: “RIO2 structure”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #148680 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6FDN
Type: protein
Length: 484 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase RIO2
EC: 2.7.11.1
UniProt: Q9BVS4
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase RIO2 (EC 2.7.11.1)	protein	232	37% helix, 22% strand	Q9BVS4
B	SERINE/THREONINE-protein kinase RIO2 (EC 2.7.11.1)	protein	252	42% helix, 21% strand	Q9BVS4

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.74	0.97	26	empty
2	209	0.67	0.85	27	empty
3	192	0.62	0.82	27	empty
4	311	0.56	0.75	28	empty
5	158	0.50	0.78	22	empty

Interfaces

1 interface between chains.

A–B · 1552 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6FDN · Rio2 structure · the same entry in another collection · chain A against A, TM-score 1.00
Q9BVS4 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase RIO2 (Q9BVS4) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BVS4
Elsewhere: RCSB PDB 6FDN · PDBe 6FDN · UniProt Q9BVS4

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