UniProt Q99814
Endothelial PAS domain-containing protein 1 (Q99814)
Endothelial PAS domain-containing protein 1 (UniProt Q99814): 54 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q99814
- Protein
- Endothelial PAS domain-containing protein 1
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 24 · 15 records with a druggable one
Structures
55 records of Q99814 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1P97 | NMR structure of the C-terminal PAS domain of HIF2a | solution nmr | A | — | — |
| 1P97 | NMR structure of the C-terminal pas domain of HIF2A | solution nmr | A | — | — |
| 2A24 | HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer | solution nmr | A | — | — |
| 2A24 | Haddock structure of hif-2A/ARNT pas-B heterodimer | solution nmr | A | — | — |
| 3F1N | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | A | — | — |
| 3F1N | Crystal structure of a high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | A | — | — |
| 3F1O | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | A | — | — |
| 3F1O | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | A | — | — |
| 3F1P | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains | x-ray diffraction | A | — | — |
| 3F1P | Crystal structure of a high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains | x-ray diffraction | A | — | — |
| 3H7W | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | A | — | — |
| 3H7W | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | A | — | — |
| 3H82 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | A | — | — |
| 3H82 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | A | — | — |
| 4GHI | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | A | — | — |
| 4GHI | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | A | — | — |
| 4GS9 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | A | — | — |
| 4GS9 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | A | — | — |
| 4PKY | ARNT/HIF transcription factor/coactivator complex | x-ray diffraction | G | — | — |
| 4PKY | ARNT/HIF transcription FACTOR/COACTIVATOR complex | x-ray diffraction | G | — | — |
| 4XT2 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | A, C | — | — |
| 4XT2 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | A, C | — | — |
| 5KIZ | Solution Structure of a repacked version of HIF-2 alpha PAS-B | solution nmr | A | — | — |
| 5KIZ | Solution structure of a repacked version of hif-2 alpha pas-B | solution nmr | A | — | — |
| 5TBM | Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | 79A | 2 (best 0.81) |
| 5TBM | Crystal structure of PT2385 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | 79A | — |
| 5UFP | Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | 86D | — |
| 5UFP | Crystal structure of PT2399 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | 86D | — |
| 6CZW | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | FO7 | 2 (best 0.80) |
| 6CZW | Crystal structure of PT1940 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | FO7 | — |
| 6D09 | Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | FOJ | 2 (best 0.80) |
| 6D09 | Crystal structure of PT2440 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | FOJ | — |
| 6D0B | Crystal structure of PT1614 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | FOV | — |
| 6D0C | Crystal structure of HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | — | — |
| 6I7Q | Structure of pvhl-elongin B-elongin C (vcb) in complex with hydroxylated-hif-2ALPHA (523-542) in… | x-ray diffraction | H | — | — |
| 6I7R | Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in… | x-ray diffraction | H | — | — |
| 6I7R | Structure of pvhl-elongin B-elongin C (vcb) in complex with hydroxylated-hif-2ALPHA (523-542) in… | x-ray diffraction | H | — | — |
| 6X21 | Crystal structure of PT1673 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | UKJ | — |
| 6X28 | Crystal structure of PT2243 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | ULG | 2 (best 0.80) |
| 6X28 | Crystal structure of PT2243 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | ULG | — |
| 6X2H | Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | ULD | 2 (best 0.80) |
| 6X2H | Crystal structure of PT2863 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | ULD | — |
| 6X37 | Crystal structure of PT3245 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | A | ULS | 3 (best 0.80) |
| 6X37 | Crystal structure of PT3245 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | ULS | — |
| 6X3D | Crystal structure of PT3388 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | A | ULM | — |
| 7Q5V | Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with N-oxalylglycine (nog) and hif-2 alpha codd… | x-ray diffraction | B | MN, OGA, MG | 2 (best 0.77) |
| 7Q5X | Hif prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 2-oxoglutarate (2OG) and hif-2 alpha codd… | x-ray diffraction | B | MN, AKG | 2 (best 0.77) |
| 7UJV | Structure of PHD2 in complex with HIF2a-CODD | x-ray diffraction | A | OGA, FE | 1 (best 0.76) |
| 8CK3 | STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH… | x-ray diffraction | A | UXU | 1 (best 0.80) |
| 8CK8 | STRUCTURE OF HIF2A-ARNT HETERODIMER IN COMPLEX WITH… | x-ray diffraction | A | UYF | 1 (best 0.80) |
| 8Q5S | Anaerobic crystal structure of apo-HIF prolyl hydroxylase 2 (PHD2 181-407)in complex with acetate… | x-ray diffraction | B | — | 1 (best 0.77) |
| 8Q64 | Crystal structure of hydroxylated HIF2alpha-CODD peptide (523-542) bound to apo-HIF prolyl… | x-ray diffraction | B | — | 1 (best 0.76) |
| 8Q6D | Anaerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with… | x-ray diffraction | B | FE, AKG | 1 (best 0.77) |
| 8Q6E | Aerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with Fe(III)… | x-ray diffraction | B | FE, AKG | 1 (best 0.77) |
| Q99814 | AlphaFold monomer V2.0 prediction for endothelial pas domain- containing protein 1 (Q99814) | predicted | A | — | — |
Ligands
- AKG · 2-oxoglutaric acid · in 3 records
- FE · Fe (III) ion · in 3 records
- 79A · 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile · in 2 records
- 86D · 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile · in 2 records
- FO7 · {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol · in 2 records
- FOJ · 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile · in 2 records
- MN · Manganese (II) ion · in 2 records
- OGA · N-oxalylglycine · in 2 records
- ULD · cis-3-({(1S)-7-[dihydroxy(trifluoromethyl)-lambda~4~-sulfanyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)cyclobutane-1-carbonitrile · in 2 records
- ULG · (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol · in 2 records
- ULS · 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile · in 2 records
- FOV · N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline · in 1 record
- MG · Magnesium ion · in 1 record
- UKJ · 1-(3-bromo-5-fluorophenoxy)-4-[(difluoromethyl) sulfonyl]-2-nitrobenzene · in 1 record
- ULM · (6R,7S)-4-[(3,3-difluorocyclobutyl)oxy]-6-fluoro-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol · in 1 record
- UXU · (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol · in 1 record
- UYF · (4~{S})-1-cyclohexyloxy-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol · in 1 record
Experiment against prediction
- 4PKY chain G against the predicted model Q99814: TM-score 0.98, RMSD 0.54 Å
- 4PKY chain G against the predicted model Q99814: TM-score 0.98, RMSD 0.54 Å
- 5UFP chain A against the predicted model Q99814: TM-score 0.98, RMSD 0.83 Å
- 5UFP chain A against the predicted model Q99814: TM-score 0.98, RMSD 0.83 Å
- 5TBM chain A against the predicted model Q99814: TM-score 0.98, RMSD 0.85 Å
- 5TBM chain A against the predicted model Q99814: TM-score 0.98, RMSD 0.85 Å
- 6X3D chain A against the predicted model Q99814: TM-score 0.96, RMSD 0.83 Å
- 3H7W chain A against the predicted model Q99814: TM-score 0.96, RMSD 0.71 Å
- 3H7W chain A against the predicted model Q99814: TM-score 0.96, RMSD 0.71 Å
- 4GS9 chain A against the predicted model Q99814: TM-score 0.96, RMSD 0.71 Å
Elsewhere
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