Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains, with an internally-bound artificial ligand

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 37% strand (DSSP).

Ligands and binding sites

• 2XY · N-[2-nitro-4-(trifluoromethyl)phenyl]morpholin-4-amine · ligand · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 935 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 3F1O · Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS… · the same entry in another collection · chain A against A, TM-score 1.00
• Q99814 · AlphaFold monomer V2.0 prediction for endothelial pas domain- containing protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.95
• P27540 · AlphaFold monomer V2.0 prediction for aryl hydrocarbon receptor nuclear translocator… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q99814
• Every structure of UniProt P27540
• Elsewhere: RCSB PDB 3F1O · PDBe 3F1O · UniProt Q99814 · UniProt P27540