UniProt P27540
Aryl hydrocarbon receptor nuclear translocator (P27540)
Aryl hydrocarbon receptor nuclear translocator (UniProt P27540): 51 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P27540
- Protein
- Aryl hydrocarbon receptor nuclear translocator
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 2 records with a druggable one
Structures
52 records of P27540 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1X0O | human ARNT C-terminal PAS domain | solution nmr | A | — | — |
| 1X0O | Human arnt C-terminal pas domain | solution nmr | A | — | — |
| 2A24 | HADDOCK Structure of HIF-2a/ARNT PAS-B Heterodimer | solution nmr | B | — | — |
| 2A24 | Haddock structure of hif-2A/ARNT pas-B heterodimer | solution nmr | B | — | — |
| 2B02 | Crystal Structure of ARNT PAS-B Domain | x-ray diffraction | A | — | — |
| 2B02 | Crystal structure of arnt pas-B domain | x-ray diffraction | A | — | — |
| 2HV1 | HADDOCK structure of ARNT PAS-B Homodimer | solution nmr | A, B | — | — |
| 2HV1 | Haddock structure of arnt pas-B homodimer | solution nmr | A, B | — | — |
| 2K7S | Human ARNT C-Terminal PAS Domain, 3 Residue IB slip | solution nmr | A | — | — |
| 2K7S | Human arnt C-terminal pas domain, 3 residue ib slip | solution nmr | A | — | — |
| 3F1N | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | B | — | — |
| 3F1N | Crystal structure of a high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | B | — | — |
| 3F1O | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | B | — | — |
| 3F1O | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | B | — | — |
| 3F1P | Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains | x-ray diffraction | B | — | — |
| 3F1P | Crystal structure of a high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains | x-ray diffraction | B | — | — |
| 3H7W | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | B | — | — |
| 3H7W | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | B | — | — |
| 3H82 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains… | x-ray diffraction | B | — | — |
| 3H82 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains… | x-ray diffraction | B | — | — |
| 4EQ1 | Crystal Structure of the ARNT PAS-B homodimer | x-ray diffraction | A, B | — | — |
| 4EQ1 | Crystal structure of the arnt pas-B homodimer | x-ray diffraction | A, B | — | — |
| 4GHI | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | B | — | — |
| 4GHI | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | B | — | — |
| 4GS9 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | B | — | — |
| 4GS9 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | B | — | — |
| 4H6J | Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1… | x-ray diffraction | B | — | — |
| 4H6J | Identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1… | x-ray diffraction | B | — | — |
| 4LPZ | ARNT transcription factor/coactivator complex | x-ray diffraction | A, B | — | — |
| 4LPZ | Arnt transcription FACTOR/COACTIVATOR complex | x-ray diffraction | A, B | — | — |
| 4PKY | ARNT/HIF transcription factor/coactivator complex | x-ray diffraction | A, D | — | — |
| 4PKY | ARNT/HIF transcription FACTOR/COACTIVATOR complex | x-ray diffraction | A, D | — | — |
| 4XT2 | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in… | x-ray diffraction | B, D | — | — |
| 4XT2 | Crystal structure of the high affinity heterodimer of HIF2 alpha and arnt C-terminal pas domains in… | x-ray diffraction | B, D | — | — |
| 5TBM | Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | B | — | 1 (best 0.46) |
| 5TBM | Crystal structure of PT2385 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 5UFP | Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 5UFP | Crystal structure of PT2399 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 5V0L | Crystal structure of the ahr-arnt heterodimer in complex with the dre | x-ray diffraction | A | — | — |
| 6CZW | Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | B | — | 1 (best 0.28) |
| 6CZW | Crystal structure of PT1940 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6D09 | Crystal structure of PT2440 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6D0B | Crystal structure of PT1614 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6D0C | Crystal structure of HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6X21 | Crystal structure of PT1673 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6X28 | Crystal structure of PT2243 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6X2H | Crystal structure of PT2863 bound to HIF2a-B*:ARNT-B* complex | x-ray diffraction | B | — | 1 (best 0.61) |
| 6X2H | Crystal structure of PT2863 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6X37 | Crystal structure of PT3245 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 6X3D | Crystal structure of PT3388 bound to HIF2A-B*:ARNT-B* complex | x-ray diffraction | B | — | — |
| 8G4A | Human ARNT PAS-B complexed with KG-548 small molecule | x-ray diffraction | A, B | YL8 | 4 (best 0.71) |
| P27540 | AlphaFold monomer V2.0 prediction for aryl hydrocarbon receptor nuclear translocator (P27540) | predicted | A | — | — |
Ligands
- YL8 · 5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole · in 1 record
Experiment against prediction
- 4PKY chain D against the predicted model P27540: TM-score 0.99, RMSD 0.45 Å
- 4PKY chain D against the predicted model P27540: TM-score 0.99, RMSD 0.45 Å
- 4PKY chain A against the predicted model P27540: TM-score 0.99, RMSD 0.45 Å
- 4PKY chain A against the predicted model P27540: TM-score 0.99, RMSD 0.45 Å
- 4LPZ chain A against the predicted model P27540: TM-score 0.98, RMSD 0.47 Å
- 4LPZ chain A against the predicted model P27540: TM-score 0.98, RMSD 0.47 Å
- 4LPZ chain B against the predicted model P27540: TM-score 0.98, RMSD 0.49 Å
- 4LPZ chain B against the predicted model P27540: TM-score 0.98, RMSD 0.49 Å
- 8G4A chain A against the predicted model P27540: TM-score 0.97, RMSD 0.72 Å
- 8G4A chain B against the predicted model P27540: TM-score 0.96, RMSD 0.92 Å
Elsewhere
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