MolNFT v1 · #98983 · protein

Arnt transcription FACTOR/COACTIVATOR complex

4LPZ · Aryl hydrocarbon receptor nuclear translocator: “Arnt transcription FACTOR/COACTIVATOR complex”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #98983 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4LPZ
Type: protein
Length: 255 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aryl hydrocarbon receptor nuclear translocator; Transforming acidic…
UniProt: P27540
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 4 distinct chains · 43% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aryl hydrocarbon receptor nuclear translocator	protein	96	29% helix, 40% strand	P27540
B	Aryl hydrocarbon receptor nuclear translocator	protein	97	29% helix, 40% strand	P27540
C	Transforming acidic coiled-coil-containing protein 3	protein	31	87% helix, 0% strand	—
D	Transforming acidic coiled-coil-containing protein 3	protein	31	87% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	116	0.45	0.78	20	empty

Interfaces

4 interfaces between chains.

C–D · 818 Å² buried · 1 hydrogen bond · protein-protein
A–B · 725 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 425 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 228 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4LPZ · ARNT transcription factor/coactivator complex · the same entry in another collection · chain A against A, TM-score 1.00
P27540 · AlphaFold monomer V2.0 prediction for aryl hydrocarbon receptor nuclear translocator… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27540
Elsewhere: RCSB PDB 4LPZ · PDBe 4LPZ · UniProt P27540

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