UniProt Q96S52
GPI transamidase component PIG-S (Q96S52)
GPI transamidase component PIG-S (UniProt Q96S52): 5 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96S52
- Protein
- GPI transamidase component PIG-S
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 31 · 4 records with a druggable one
Structures
6 records of Q96S52 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7W72 | Structure of a human glycosylphosphatidylinositol (GPI) transamidase | electron microscopy | S | NAG | 8 (best 0.87) |
| 7W72 | Structure of a human glycosylphosphatidylinositol (gpi) transamidase | electron microscopy | S | NAG | — |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 Angstrom… | electron microscopy | S | NAG, CLR, CDL | 7 (best 0.88) |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 ångström… | electron microscopy | S | NAG, CLR, CDL | — |
| 8IMY | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | electron microscopy | S | LBN, 80T, NAG, 6OU, Y01 | 9 (best 0.86) |
| Q96S52 | AlphaFold monomer V2.0 prediction for gpi transamidase component pig-S (Q96S52) | predicted | A | — | 7 (best 0.65) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- CDL · Cardiolipin · in 2 records
- CLR · Cholesterol · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- 80T · [(2R)-1-hexadecanoyloxy-3-[[3-[[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propan-2-yl] (Z)-octadec-9-enoate · in 1 record
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 8IMY chain S against the predicted model Q96S52: TM-score 0.91, RMSD 2.99 Å
- 7W72 chain S against the predicted model Q96S52: TM-score 0.90, RMSD 3.10 Å
- 7W72 chain S against the predicted model Q96S52: TM-score 0.90, RMSD 3.10 Å
- 7WLD chain S against the predicted model Q96S52: TM-score 0.88, RMSD 3.20 Å
- 7WLD chain S against the predicted model Q96S52: TM-score 0.88, RMSD 3.20 Å
- 8IMY chain S against the predicted model Q9U6Y3: TM-score 0.20, RMSD 5.80 Å
Elsewhere
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