UniProt Q96RU2
Ubiquitin carboxyl-terminal hydrolase 28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (UniProt Q96RU2), EC 3.4.19.12: 22 experimental structures on GenesisL1, 7 ligands bound, 46 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q96RU2
- Protein
- Ubiquitin carboxyl-terminal hydrolase 28
- EC
- 3.4.19.12
- Experimental structures
- 22
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 46 · 8 records with a druggable one
Structures
22 records of Q96RU2 in the MolNFT archive: 22 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LVA | NMR solution structure of the N-terminal domain of human USP28, Northeast structural genomics… | solution nmr | A | — | — |
| 2LVA | NMR solution structure of the N-terminal domain of human USP28, northeast structural genomics… | solution nmr | A | — | — |
| 2MUU | The Proteolytic Activity of Ubiquitin-specific Protease 28 Is Modulated by the N-terminal Domain | solution nmr | A | — | — |
| 2MUU | The proteolytic activity of ubiquitin-specific protease 28 is modulated by the N-terminal domain | solution nmr | A | — | — |
| 6H4H | USP28 catalytic domain variant E593D in complex with ubpa | x-ray diffraction | A, B | AYE | — |
| 6H4I | Usp28 catalytic domain apo | x-ray diffraction | A, C | SO4 | — |
| 6H4I | USP28 catalytic domain apo | x-ray diffraction | A, C | SO4 | — |
| 6HEH | Structure of the catalytic domain of USP28 (insertion deleted) | x-ray diffraction | A | CL | 3 (best 0.62) |
| 6HEH | Structure of the catalytic domain of USP28 (insertion deleted) | x-ray diffraction | A | CL | — |
| 6HEI | Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA | x-ray diffraction | A | — | 5 (best 0.71) |
| 6HEI | Structure of the catalytic domain of USP28 (insertion deleted) bound to ubiquitin-pa | x-ray diffraction | A | AYE | — |
| 6HEJ | Structure of human USP28 | x-ray diffraction | A, B | SO4 | 8 (best 0.81) |
| 6HEJ | Structure of human USP28 | x-ray diffraction | A, B | SO4 | — |
| 6HEK | Structure of human USP28 bound to Ubiquitin-PA | x-ray diffraction | A, C | CL | — |
| 6HEK | Structure of human USP28 bound to ubiquitin-pa | x-ray diffraction | A, C | AYE, CL | — |
| 7TUO | Crystal structure analysis of human USP28 complex with a compound | x-ray diffraction | A | KL9, CL | — |
| 8HJE | Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28 | x-ray diffraction | A | VIS | 2 (best 0.73) |
| 8P14 | USP28 USP domain in complex with Vismodegib | x-ray diffraction | A | VIS, CL | 4 (best 0.73) |
| 8P19 | USP28 USP domain apo | x-ray diffraction | A | CL | 3 (best 0.69) |
| 8P1P | USP28 in complex with AZ1 | x-ray diffraction | A, B | CL, WF0 | 12 (best 0.77) |
| 8P1Q | USP28 in complex with FT206 | x-ray diffraction | A, B | WFT | 9 (best 0.70) |
| Q96RU2 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 28 (Q96RU2) | — | — | — |
Ligands
- CL · Chloride ion · in 8 records
- SO4 · Sulfate ion · in 4 records
- AYE · prop-2-en-1-amine · in 3 records
- VIS · 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide · in 2 records
- KL9 · 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide · in 1 record
- WF0 · 2-[[5-bromanyl-2-[[4-fluoranyl-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol · in 1 record
- WFT · 3-azanyl-N-[(2S)-6-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methyl-thieno[2,3-b]pyridine-2-carboxamide · in 1 record
Elsewhere
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