MolNFT v1 · #151135 · protein

Structure of human USP28

6HEJ · Ubiquitin carboxyl-terminal hydrolase 28: “Structure of human USP28”. X-ray diffraction, 1 ligand (SO4), 8 pockets (best druggability 0.81). MolNFT v1 #151135 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6HEJ
Type: protein
Length: 845 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase 28
EC: 3.4.19.12
UniProt: Q96RU2
Ligands: SO4
Pockets: 8 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12)	protein	436	47% helix, 20% strand	Q96RU2
B	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12)	protein	409	49% helix, 19% strand	Q96RU2

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	595	0.81	0.86	82	empty
2	334	0.72	0.84	43	empty
3	405	0.66	0.79	44	empty
4	144	0.46	0.76	25	empty
5	74	0.37	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 1580 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6HEJ · Structure of human USP28 · the same entry in another collection · chain A against A, TM-score 1.00
Q96RU2 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 28 (Q96RU2) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96RU2
Elsewhere: RCSB PDB 6HEJ · PDBe 6HEJ · UniProt Q96RU2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.