UniProt Q96I99
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (Q96I99)
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (UniProt Q96I99), EC 6.2.1.4: 7 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 27 pockets. Binding sites, druggability and experiment…
- UniProt
- Q96I99
- Protein
- Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
- EC
- 6.2.1.4
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 27 · 7 records with a druggable one
Structures
8 records of Q96I99 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WCV | Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | B | TUY | 4 (best 0.78) |
| 6WCV | Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | B | TUY | — |
| 7MSR | Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinyl-phosphate, magnesium ion… | x-ray diffraction | B | DCA, MG, ZNS | 4 (best 0.78) |
| 7MSS | Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinate, magnesium ion and CoA | x-ray diffraction | B | COA, PO4, MG | 3 (best 0.81) |
| 7MST | Phosphorylated human E105Qa GTP-specific succinyl-CoA synthetase complexed with coenzyme A | x-ray diffraction | B | — | 5 (best 0.76) |
| 8Z02 | CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | B | PO4 | 4 (best 0.80) |
| 8Z03 | Lactate bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | B | COA, PO4, 2OP, MG | 5 (best 0.77) |
| Q96I99 | AlphaFold monomer V2.0 prediction for succinate--CoA ligase [GDP- forming] subunit beta… | predicted | A | — | 2 (best 0.70) |
Ligands
- MG · Magnesium ion · in 3 records
- PO4 · Phosphate ion · in 3 records
- COA · Coenzyme A · in 2 records
- TUY · (3S,5S,9R,20R,21R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,20, 21-pentahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphadocosan-22-oic acid 3,5-dioxide (non-preferred name) · in 2 records
- 2OP · (2S)-2-hydroxypropanoic acid · in 1 record
- DCA · Desulfo-coenzyme A · in 1 record
- ZNS · 4-oxo-4-(phosphonooxy)butanoic acid · in 1 record
Experiment against prediction
- 8Z02 chain B against the predicted model Q96I99: TM-score 0.97, RMSD 1.18 Å
- 7MST chain B against the predicted model Q96I99: TM-score 0.97, RMSD 1.27 Å
- 6WCV chain B against the predicted model Q96I99: TM-score 0.97, RMSD 1.29 Å
- 6WCV chain B against the predicted model Q96I99: TM-score 0.97, RMSD 1.29 Å
- 8Z03 chain B against the predicted model Q96I99: TM-score 0.96, RMSD 1.55 Å
- 7MSS chain B against the predicted model Q96I99: TM-score 0.96, RMSD 1.61 Å
- 7MSR chain B against the predicted model Q96I99: TM-score 0.96, RMSD 1.65 Å
Elsewhere
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