UniProt Q96DE0
U8 snoRNA-decapping enzyme (Q96DE0)
U8 snoRNA-decapping enzyme (UniProt Q96DE0), EC 3.6.1.62, 3.6.1.64: 22 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96DE0
- Protein
- U8 snoRNA-decapping enzyme
- EC
- 3.6.1.62, 3.6.1.64
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 37 · 9 records with a druggable one
Structures
23 records of Q96DE0 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XSQ | Crystal structure of human Nudix motif 16 (NUDT16) in complex with IMP and magnesium | x-ray diffraction | A | — | — |
| 2XSQ | Crystal structure of human nudix motif 16 (NUDT16) in complex with imp and magnesium | x-ray diffraction | A | — | — |
| 3COU | Crystal structure of human Nudix motif 16 (NUDT16) | x-ray diffraction | A | — | — |
| 3COU | Crystal structure of human nudix motif 16 (NUDT16) | x-ray diffraction | A | — | — |
| 3MGM | Crystal structure of human NUDT16 | x-ray diffraction | A, B | — | — |
| 3MGM | Crystal structure of human NUDT16 | x-ray diffraction | A, B | — | — |
| 5VY2 | Crystal structure of the F36A mutant of HsNUDT16 | x-ray diffraction | A, B | NA | 3 (best 0.71) |
| 5VY2 | Crystal structure of the F36A mutant of HSNUDT16 | x-ray diffraction | A, B | NA | — |
| 5W6X | Crystal structure of the HsNUDT16 in complex with Mg+2 and ADP-ribose | x-ray diffraction | A, B | APR, MG | 3 (best 0.75) |
| 5W6X | Crystal structure of the HSNUDT16 in complex with MG+2 and ADP-ribose | x-ray diffraction | A, B | APR, MG | — |
| 5W6Z | Crystal structure of the H24W mutant of HsNUDT16 | x-ray diffraction | A, B, D, E | NA | 8 (best 0.77) |
| 5W6Z | Crystal structure of the H24W mutant of HSNUDT16 | x-ray diffraction | A, B, D, E | NA | — |
| 5WJI | Crystal structure of the F61S mutant of HsNUDT16 | x-ray diffraction | A, B | CL, SO4 | 3 (best 0.75) |
| 5WJI | Crystal structure of the F61S mutant of HSNUDT16 | x-ray diffraction | A, B | CL, SO4 | — |
| 6B09 | Crystal structure of HsNUDT16 in complex with diADPR (soaked) | x-ray diffraction | A, B | C7G, MG, NA | 3 (best 0.75) |
| 6B09 | Crystal structure of HSNUDT16 in complex with diadpr (soaked) | x-ray diffraction | A, B | C7G, MG, NA | — |
| 6CO2 | Structure of an engineered protein (NUDT16TI) in complex with 53BP1 Tudor domains | x-ray diffraction | A, B | — | 5 (best 0.71) |
| 6CO2 | Structure of an engineered protein (NUDT16TI) in complex with 53BP1 tudor domains | x-ray diffraction | A, B | — | — |
| 6X7U | Crystal Structure of the Human Nudix Hydrolase Nudt16 in complex with FAD | x-ray diffraction | A, C | FAD, MN, AMP | 3 (best 0.73) |
| 6X7U | Crystal structure of the human nudix hydrolase NUDT16 in complex with FAD | x-ray diffraction | A, C | FAD, MN, AMP | — |
| 6X7V | Crystal Structure of the Human Nudix Hydrolase Nudt16 | x-ray diffraction | A, B, C, D | MN, CL | 8 (best 0.76) |
| 6X7V | Crystal structure of the human nudix hydrolase NUDT16 | x-ray diffraction | A, B, C, D | MN, CL | — |
| Q96DE0 | AlphaFold monomer V2.0 prediction for U8 snorna-decapping enzyme (Q96DE0) | predicted | A | — | 1 (best 0.57) |
Ligands
- NA · Sodium ion · in 6 records
- CL · Chloride ion · in 4 records
- MG · Magnesium ion · in 4 records
- MN · Manganese (II) ion · in 4 records
- AMP · Adenosine monophosphate · in 2 records
- APR · Adenosine-5-diphosphoribose · in 2 records
- C7G · [(2~{R},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-[(2~{S},3~{S},4~{S},5~{S})-5-[[[[(2~{R},3~{R},4~{S}, 5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate · in 2 records
- FAD · Flavin-adenine dinucleotide · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 5W6X chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.40 Å
- 5W6X chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.40 Å
- 6B09 chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.56 Å
- 6B09 chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.56 Å
- 5VY2 chain A against the predicted model Q96DE0: TM-score 0.99, RMSD 0.68 Å
- 5VY2 chain A against the predicted model Q96DE0: TM-score 0.99, RMSD 0.68 Å
- 5WJI chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.61 Å
- 5WJI chain B against the predicted model Q96DE0: TM-score 0.99, RMSD 0.61 Å
- 2XSQ chain A against the predicted model Q96DE0: TM-score 0.99, RMSD 0.68 Å
- 2XSQ chain A against the predicted model Q96DE0: TM-score 0.99, RMSD 0.68 Å
Elsewhere
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