UniProt Q96DC9
Ubiquitin thioesterase OTUB2 (Q96DC9)
Ubiquitin thioesterase OTUB2 (UniProt Q96DC9), EC 3.4.19.12: 19 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96DC9
- Protein
- Ubiquitin thioesterase OTUB2
- EC
- 3.4.19.12
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 13
Structures
20 records of Q96DC9 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1TFF | Structure of Otubain-2 | x-ray diffraction | A | — | — |
| 1TFF | Structure of otubain-2 | x-ray diffraction | A | — | — |
| 4FJV | Crystal Structure of Human Otubain2 and Ubiquitin Complex | x-ray diffraction | A, C | — | — |
| 4FJV | Crystal structure of human OTUBAIN2 and ubiquitin complex | x-ray diffraction | A, C | — | — |
| 5QIO | Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with P11 | x-ray diffraction | A | UNL, J4Y | — |
| 5QIO | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with P11 | x-ray diffraction | A | UNL, J4Y | — |
| 5QIP | Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102153 | x-ray diffraction | A | J51 | — |
| 5QIP | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102153 | x-ray diffraction | A | J51 | — |
| 5QIQ | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0103050 | x-ray diffraction | A | J5A | — |
| 5QIR | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102305 | x-ray diffraction | A | J5D | — |
| 5QIS | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102500 | x-ray diffraction | A | J5G | — |
| 5QIT | Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102821 | x-ray diffraction | A | J5J | — |
| 5QIT | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102821 | x-ray diffraction | A | J5J | — |
| 5QIU | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0103011 | x-ray diffraction | A | J5M, UNL | — |
| 5QIV | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102998 | x-ray diffraction | A | J5P, UNL | — |
| 5QIW | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102660 | x-ray diffraction | A | J5S, UNL | — |
| 5QIX | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0103007 | x-ray diffraction | A | J5V, UNL | — |
| 5QIY | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0102954 | x-ray diffraction | A | J61, UNL | — |
| 5QIZ | Covalent fragment group deposition -- crystal structure of OUTB2 in complex with pcm-0103080 | x-ray diffraction | A | J64, UNL | — |
| Q96DC9 | AlphaFold monomer V2.0 prediction for ubiquitin thioesterase OTUB2 (Q96DC9) | predicted | A | — | — |
Ligands
- UNL · Unknown ligand · in 8 records
- J4Y · (1S,2S)-N'-(chloroacetyl)-2-phenylcyclopropane-1-carbohydrazide · in 2 records
- J51 · benzyl acetylcarbamate · in 2 records
- J5J · N-[(E)-(3-methylphenyl)methylidene]acetamide · in 2 records
- J5A · N-[(4-bromothiophen-2-yl)methyl]acetamide · in 1 record
- J5D · N-[(4-fluoro-3-methylphenyl)methyl]acetamide · in 1 record
- J5G · N-(5-methyl-1,2-oxazol-3-yl)acetamide · in 1 record
- J5M · N-{3-[3-(trifluoromethyl)phenyl]prop-2-yn-1-yl}acetamide · in 1 record
- J5P · N'-acetyl-2-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetohydrazide · in 1 record
- J5S · N-[(E)-(4-methylphenyl)methylidene]acetamide · in 1 record
- J5V · N-(3-phenylprop-2-yn-1-yl)acetamide · in 1 record
- J61 · N'-acetyl-2-chlorobenzohydrazide · in 1 record
- J64 · N-[(5-chlorothiophen-2-yl)methyl]acetamide · in 1 record
Experiment against prediction
- 5QIP chain A against the predicted model Q96DC9: TM-score 0.99, RMSD 0.40 Å
- 5QIP chain A against the predicted model Q96DC9: TM-score 0.99, RMSD 0.40 Å
- 5QIX chain A against the predicted model Q96DC9: TM-score 0.99, RMSD 0.52 Å
- 4FJV chain C against the predicted model Q96DC9: TM-score 0.99, RMSD 0.75 Å
- 4FJV chain C against the predicted model Q96DC9: TM-score 0.99, RMSD 0.75 Å
- 5QIO chain A against the predicted model Q96DC9: TM-score 0.98, RMSD 0.76 Å
- 5QIO chain A against the predicted model Q96DC9: TM-score 0.98, RMSD 0.76 Å
- 4FJV chain A against the predicted model Q96DC9: TM-score 0.98, RMSD 0.94 Å
- 4FJV chain A against the predicted model Q96DC9: TM-score 0.98, RMSD 0.94 Å
- 5QIY chain A against the predicted model Q96DC9: TM-score 0.98, RMSD 0.76 Å
Elsewhere
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