UniProt Q923J1
Transient receptor potential cation channel subfamily M member 7 (Q923J1)
Transient receptor potential cation channel subfamily M member 7 (UniProt Q923J1), EC 2.7.1.37, 2.7.11.1: 18 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 250 pockets. Binding sites, druggability…
- UniProt
- Q923J1
- Protein
- Transient receptor potential cation channel subfamily M member 7
- EC
- 2.7.1.37, 2.7.11.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 250 · 15 records with a druggable one
Structures
19 records of Q923J1 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IA9 | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (amppnp complex) | x-ray diffraction | A, B | ZN, ANP | 7 (best 0.62) |
| 1IA9 | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (amppnp complex) | x-ray diffraction | A, B | — | — |
| 1IAH | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (ADP-mg complex) | x-ray diffraction | A, B | ZN, ADP, MG | 7 (best 0.60) |
| 1IAH | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (ADP-mg complex) | x-ray diffraction | A, B | — | — |
| 1IAJ | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (apo) | x-ray diffraction | A, B | ZN | 9 (best 0.53) |
| 1IAJ | Crystal structure of the atypical protein kinase domain of a TRP ca-channel, chak (apo) | x-ray diffraction | A, B | — | — |
| 5ZX5 | 3.3 angstrom structure of mouse TRPM7 with EDTA | electron microscopy | A, B, C, D | Y01 | 20 (best 0.80) |
| 5ZX5 | 3.3 ångström structure of mouse TRPM7 with edta | electron microscopy | A, B, C, D | Y01 | — |
| 8SI2 | Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state | electron microscopy | A, B, C, D | POV, CLR, DU0, NA | 20 (best 0.87) |
| 8SI3 | Cryo-EM structure of TRPM7 in GDN detergent in apo state | electron microscopy | A, B, C, D | POV, CLR, DU0, CA | 20 (best 0.83) |
| 8SI4 | Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in open state | electron microscopy | A, B, C, D | POV, CLR, DU0, CA | 20 (best 0.81) |
| 8SI5 | Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open state | electron microscopy | A, B, C, D | POV, CLR, DU0, ZY8, CA | 20 (best 0.80) |
| 8SI6 | Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in closed state | electron microscopy | A, B, C, D | POV, CLR, DU0, ZY8, CA | 20 (best 0.86) |
| 8SI7 | Cryo-EM structure of TRPM7 in GDN detergent in complex with inhibitor VER155008 in closed state | electron microscopy | A, B, C, D | POV, 3FD, CLR, DU0, CA | 20 (best 0.87) |
| 8SI8 | Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor VER155008 in… | electron microscopy | A, B, C, D | POV, 3FD, CLR, DU0, CA | 20 (best 0.82) |
| 8SIA | Cryo-EM structure of TRPM7 N1098Q mutant in GDN detergent in complex with inhibitor NS8593 in… | electron microscopy | A, B, C, D | POV, DU0, 6RA, CA, CLR | 20 (best 0.86) |
| 8SIB | Cryo-EM structure of TRPM7 MHR1-3 domain | electron microscopy | A | — | 7 (best 0.65) |
| 8W2L | TRPM7 structure in complex with anticancer agent CCT128930 in closed state | electron microscopy | A, B, C, D | POV, CLR, M05, DU0, CA | 20 (best 0.87) |
| Q923J1 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M… | predicted | A | — | 20 (best 0.81) |
Ligands
- CLR · Cholesterol · in 9 records
- DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol · in 9 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 9 records
- CA · Calcium ion · in 8 records
- ZN · Zinc ion · in 3 records
- 3FD · 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl) methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- ZY8 · (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol · in 2 records
- 6RA · N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine · in 1 record
- ADP · Adenosine-5'-diphosphate · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- M05 · 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 8SIB chain A against the predicted model Q923J1: TM-score 0.95, RMSD 2.14 Å
- 8W2L chain A against the predicted model Q923J1: TM-score 0.94, RMSD 2.83 Å
- 8SI6 chain A against the predicted model Q923J1: TM-score 0.93, RMSD 3.12 Å
- 8SI3 chain A against the predicted model Q923J1: TM-score 0.93, RMSD 3.13 Å
- 8SI2 chain A against the predicted model Q923J1: TM-score 0.93, RMSD 3.16 Å
- 8SI7 chain A against the predicted model Q923J1: TM-score 0.93, RMSD 3.20 Å
- 8SI4 chain A against the predicted model Q923J1: TM-score 0.92, RMSD 3.25 Å
- 8SI8 chain A against the predicted model Q923J1: TM-score 0.92, RMSD 3.26 Å
- 8SIA chain A against the predicted model Q923J1: TM-score 0.92, RMSD 3.36 Å
- 5ZX5 chain A against the predicted model Q923J1: TM-score 0.89, RMSD 2.93 Å
Elsewhere
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