ZY8 · (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-8aH-4,8-methanobis[1]benzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol

Binding sites

ZY8 in 2 structures; the first of them:

• 8SI5 · Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in open… · ZY8 A1314 · binds MET741, SER744, ASP745, MET748, ASN752, MET753, ARG754, LYS777 and 4 more
• 8SI6 · Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in complex with agonist naltriben in closed… · ZY8 A1314 · binds PHE856, ASP922, PHE924, ASP978, PHE979, ALA981, VAL982, VAL990 and 7 more

Residues it binds most

ASP 8, MET 8, PHE 4, VAL 8, ARG 8, ALA 4, ASN 4, GLN 4, LEU 4, LYS 4 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol
• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
• CA · Calcium ion