UniProt Q8ZRZ3
Na(+)/H(+) antiporter NhaA (Q8ZRZ3)
Na(+)/H(+) antiporter NhaA (UniProt Q8ZRZ3): 6 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8ZRZ3
- Protein
- Na(+)/H(+) antiporter NhaA
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 44 · 4 records with a druggable one
Structures
7 records of Q8ZRZ3 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7A0W | Structure of dimeric sodium proton antiporter NhaA, at pH 8.5, crystallized with chimeric Fab… | x-ray diffraction | A, B | CDL, 3PH, PO4 | 13 (best 0.78) |
| 7A0W | Structure of dimeric sodium proton antiporter nhaa, at pH 8.5, crystallized with chimeric Fab… | x-ray diffraction | A, B | CDL, 3PH, PO4 | — |
| 7A0X | Structure of dimeric sodium proton antiporter NhaA, at pH 6.0, crystallized with chimeric Fab… | x-ray diffraction | A, B | CDL, 3PH, PO4, 3PE | 11 (best 0.78) |
| 7A0X | Structure of dimeric sodium proton antiporter nhaa, at pH 6.0, crystallized with chimeric Fab… | x-ray diffraction | A, B | CDL, 3PH, PO4, 3PE | — |
| 7A0Y | Structure of dimeric sodium proton antiporter NhaA K300R variant, at pH 8.2, crystallized with… | x-ray diffraction | A, B | CDL, 3PH, PO4, 3PE | 14 (best 0.78) |
| 7A0Y | Structure of dimeric sodium proton antiporter nhaa K300R variant, at pH 8.2, crystallized with… | x-ray diffraction | A, B | CDL, 3PH, PO4, 3PE | — |
| Q8ZRZ3 | AlphaFold monomer V2.0 prediction for NA(+)/H(+) antiporter nhaa (Q8ZRZ3) | predicted | A | — | 6 (best 0.65) |
Ligands
Experiment against prediction
- 7A0X chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.04 Å
- 7A0X chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.04 Å
- 7A0X chain B against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.06 Å
- 7A0X chain B against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.06 Å
- 7A0Y chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.06 Å
- 7A0Y chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.06 Å
- 7A0Y chain B against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.08 Å
- 7A0Y chain B against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.08 Å
- 7A0W chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.08 Å
- 7A0W chain A against the predicted model Q8ZRZ3: TM-score 0.98, RMSD 1.08 Å
Elsewhere
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