UniProt Q8ZPX9
Streptomycin 3''-adenylyltransferase (Q8ZPX9)
Streptomycin 3''-adenylyltransferase (UniProt Q8ZPX9), EC 2.7.7.47: 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8ZPX9
- Protein
- Streptomycin 3''-adenylyltransferase
- EC
- 2.7.7.47
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 11 · 4 records with a druggable one
Structures
10 records of Q8ZPX9 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CS6 | Crystal structure of AadA - an aminoglycoside adenyltransferase | x-ray diffraction | A | — | — |
| 4CS6 | Crystal structure of aada - an aminoglycoside adenyltransferase | x-ray diffraction | A | — | — |
| 5G4A | Aada in complex with ATP and magnesium | x-ray diffraction | A, B | — | — |
| 5LPA | AadA E87Q in complex with ATP, calcium and dihydrostreptomycin | x-ray diffraction | A, B | ATP, 71R, CA, CL | 3 (best 0.74) |
| 5LPA | Aada E87Q in complex with ATP, calcium and dihydrostreptomycin | x-ray diffraction | A, B | ATP, 71R, CA, CL | — |
| 5LUH | AadA E87Q in complex with ATP, calcium and streptomycin | x-ray diffraction | A, B | CA, ATP, SRY, CL | 3 (best 0.73) |
| 5LUH | Aada E87Q in complex with ATP, calcium and streptomycin | x-ray diffraction | A, B | CA, ATP, SRY, CL | — |
| 6FZB | AadA in complex with ATP, magnesium and streptomycin | x-ray diffraction | A, B | SRY, MG, ATP, CL | 4 (best 0.74) |
| 6FZB | Aada in complex with ATP, magnesium and streptomycin | x-ray diffraction | A, B | SRY, MG, ATP, CL | — |
| Q8ZPX9 | AlphaFold monomer V2.0 prediction for aminoglycoside (3'') (9) adenylyltransferase (Q8ZPX9) | predicted | A | — | 1 (best 0.75) |
Ligands
Experiment against prediction
- 5G4A chain A against the predicted model Q8ZPX9: TM-score 0.99, RMSD 0.51 Å
- 5LUH chain B against the predicted model Q8ZPX9: TM-score 0.98, RMSD 0.35 Å
- 5LUH chain B against the predicted model Q8ZPX9: TM-score 0.98, RMSD 0.35 Å
- 5LUH chain A against the predicted model Q8ZPX9: TM-score 0.99, RMSD 0.36 Å
- 5LUH chain A against the predicted model Q8ZPX9: TM-score 0.99, RMSD 0.36 Å
- 5LPA chain A against the predicted model Q8ZPX9: TM-score 0.97, RMSD 0.36 Å
- 5LPA chain A against the predicted model Q8ZPX9: TM-score 0.97, RMSD 0.36 Å
- 5LPA chain B against the predicted model Q8ZPX9: TM-score 0.97, RMSD 0.37 Å
- 6FZB chain B against the predicted model Q8ZPX9: TM-score 0.99, RMSD 0.41 Å
- 6FZB chain B against the predicted model Q8ZPX9: TM-score 0.99, RMSD 0.41 Å
Elsewhere
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