UniProt Q8WWN8
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Q8WWN8)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (UniProt Q8WWN8): 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 8 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8WWN8
- Protein
- Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 8 · 2 records with a druggable one
Structures
13 records of Q8WWN8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KG5 | NMR Solution structure of ARAP3-SAM | solution nmr | A | — | — |
| 2KG5 | NMR solution structure of ARAP3-SAM | solution nmr | A | — | — |
| 2LNW | Identification and structural basis for a novel interaction between Vav2 and Arap3 | solution nmr | B | — | — |
| 2LNW | Identification and structural basis for a novel interaction between VAV2 and ARAP3 | solution nmr | B | — | — |
| 5JCP | RhoGAP domain of ARAP3 in complex with RhoA in the transition state | x-ray diffraction | B, A | GDP, MG, ALF | 6 (best 0.71) |
| 5JCP | Rhogap domain of ARAP3 in complex with rhoa in the transition state | x-ray diffraction | B, A | — | — |
| 5JD0 | crystal structure of ARAP3 RhoGAP domain | x-ray diffraction | A, B | — | — |
| 5JD0 | Crystal structure of ARAP3 rhogap domain | x-ray diffraction | A, B | — | — |
| 7A9B | Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide | x-ray diffraction | A, B | — | 2 (best 0.77) |
| 7A9B | Crystal structure of SHANK1 PDZ domain with ARAP3-derived peptide | x-ray diffraction | A, B | — | — |
| 7YIR | Crystal structure of N-terminal PH domain of ARAP3 protein from human | x-ray diffraction | A | — | — |
| 7YIS | Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol… | x-ray diffraction | A | 4PT | — |
| Q8WWN8 | AlphaFold monomer V2.0 prediction for arf-gap with rho-gap domain, ank repeat and pH… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5JD0 chain B against the predicted model Q8WWN8: TM-score 0.99, RMSD 0.46 Å
- 5JD0 chain B against the predicted model Q8WWN8: TM-score 0.99, RMSD 0.46 Å
- 5JD0 chain A against the predicted model Q8WWN8: TM-score 0.99, RMSD 0.59 Å
- 5JD0 chain A against the predicted model Q8WWN8: TM-score 0.99, RMSD 0.59 Å
- 7YIS chain A against the predicted model Q8WWN8: TM-score 0.96, RMSD 0.79 Å
- 7YIR chain A against the predicted model Q8WWN8: TM-score 0.93, RMSD 1.31 Å
- 5JCP chain B against the predicted model P61586: TM-score 0.46, RMSD 0.36 Å
- 5JCP chain B against the predicted model P61586: TM-score 0.46, RMSD 0.36 Å
- 5JCP chain A against the predicted model P61586: TM-score 0.45, RMSD 0.36 Å
- 5JCP chain A against the predicted model P61586: TM-score 0.45, RMSD 0.36 Å
Elsewhere
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