UniProt Q8WTW4
GATOR complex protein NPRL2 (Q8WTW4)
GATOR complex protein NPRL2 (UniProt Q8WTW4): 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WTW4
- Protein
- GATOR complex protein NPRL2
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 29 · 5 records with a druggable one
Structures
12 records of Q8WTW4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6CES | Cryo-EM structure of GATOR1-RAG | electron microscopy | N | — | — |
| 6CES | Cryo-EM structure of GATOR1-rag | electron microscopy | N | — | — |
| 6CET | Cryo-EM structure of GATOR1 | electron microscopy | N | — | 10 (best 0.83) |
| 6CET | Cryo-EM structure of GATOR1 | electron microscopy | N | — | — |
| 7T3A | GATOR1-RAG-RAGULATOR - Inhibitory Complex | electron microscopy | B | — | 2 (best 0.80) |
| 7T3A | GATOR1-rag-ragulator - inhibitory complex | electron microscopy | B | — | — |
| 7T3B | GATOR1-RAG-RAGULATOR - GAP Complex | electron microscopy | B | GDP, AF3 | 4 (best 0.75) |
| 7T3B | GATOR1-rag-ragulator - gap complex | electron microscopy | B | GDP, AF3 | — |
| 7T3C | GATOR1-RAG-RAGULATOR - Dual Complex | electron microscopy | B | GDP, AF3 | 3 (best 0.77) |
| 7T3C | GATOR1-rag-ragulator - dual complex | electron microscopy | B | GDP, AF3 | — |
| 8FW5 | Chimeric HsGATOR1-SpGtr-SpLam complex | electron microscopy | B | GDP, AF3 | 6 (best 0.77) |
| Q8WTW4 | AlphaFold monomer V2.0 prediction for gator complex protein NPRL2 (Q8WTW4) | predicted | A | — | 4 (best 0.38) |
Ligands
Experiment against prediction
- 7T3A chain B against the predicted model Q8WTW4: TM-score 0.89, RMSD 2.66 Å
- 7T3A chain B against the predicted model Q8WTW4: TM-score 0.89, RMSD 2.66 Å
- 8FW5 chain B against the predicted model Q8WTW4: TM-score 0.85, RMSD 3.25 Å
- 7T3C chain B against the predicted model Q8WTW4: TM-score 0.84, RMSD 3.20 Å
- 7T3C chain B against the predicted model Q8WTW4: TM-score 0.84, RMSD 3.20 Å
- 7T3B chain B against the predicted model Q8WTW4: TM-score 0.83, RMSD 3.41 Å
- 7T3B chain B against the predicted model Q8WTW4: TM-score 0.83, RMSD 3.41 Å
- 6CES chain N against the predicted model Q8WTW4: TM-score 0.72, RMSD 2.97 Å
- 6CES chain N against the predicted model Q8WTW4: TM-score 0.72, RMSD 2.97 Å
- 6CET chain N against the predicted model Q8WTW4: TM-score 0.71, RMSD 3.09 Å
Elsewhere
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