UniProt Q8VHX0
Voltage-dependent calcium channel gamma-3 subunit (Q8VHX0)
Voltage-dependent calcium channel gamma-3 subunit (UniProt Q8VHX0): 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 162 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8VHX0
- Protein
- Voltage-dependent calcium channel gamma-3 subunit
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 162 · 13 records with a druggable one
Structures
19 records of Q8VHX0 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7TNJ | Complex NNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at… | electron microscopy | A, B, C, D | CYZ | 20 (best 0.84) |
| 7TNJ | Complex nnnn of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at… | electron microscopy | A, B, C, D | CYZ | — |
| 7TNK | Complex GNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at… | electron microscopy | A, B, C, D | GLU, CYZ | 20 (best 0.85) |
| 7TNK | Complex gnnn of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at… | electron microscopy | A, B, C, D | CYZ | — |
| 7TNL | Complex GNGN1 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at… | electron microscopy | A, B, C, D | GLU, CYZ | 20 (best 0.84) |
| 7TNL | Complex GNGN1 of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at… | electron microscopy | A, B, C, D | CYZ | — |
| 7TNM | Complex GNGN2 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at… | electron microscopy | A, B, C, D | GLU, CYZ | 20 (best 0.84) |
| 7TNM | Complex GNGN2 of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at… | electron microscopy | A, B, C, D | CYZ | — |
| 7TNP | Complex GGGG of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at… | electron microscopy | A, B, C, D | GLU, CYZ | 20 (best 0.83) |
| 7TNP | Complex gggg of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at… | electron microscopy | A, B, C, D | CYZ | — |
| 8C1P | Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | electron microscopy | E, F, G, H | PLM, POV | 9 (best 0.53) |
| 8C1Q | Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | electron microscopy | E, F, G, H | POV | 5 (best 0.69) |
| 8C2H | Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 | electron microscopy | E, F, G, H | POV, PLM | 11 (best 0.53) |
| 8C2I | Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 | electron microscopy | E, F, G, H | POV | 11 (best 0.64) |
| 8P3T | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1 | electron microscopy | E, F, G, H | — | 4 (best 0.54) |
| 8P3U | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 2 | electron microscopy | E, F, G, H | — | 8 (best 0.56) |
| 8P3V | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 3 | electron microscopy | E, F, G, H | — | 6 (best 0.59) |
| 8P3W | Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 4 | electron microscopy | E, F, G, H | POV | 8 (best 0.53) |
| Q8VHX0 | AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-3 subunit (Q8VHX0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8P3U chain H against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.87 Å
- 8P3V chain E against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.88 Å
- 8P3V chain F against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.88 Å
- 8P3W chain H against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.90 Å
- 8C2I chain H against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.90 Å
- 8C2I chain F against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.90 Å
- 8C2H chain H against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.91 Å
- 8P3W chain G against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.90 Å
- 8C1Q chain G against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.91 Å
- 8C1Q chain F against the predicted model Q8VHX0: TM-score 0.97, RMSD 0.92 Å
Elsewhere
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