MolNFT v1 · #188351 · protein
Complex nnnn of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at low glutamate concentration (20 um) in the presence of cyclothiazide (100 um)
7TNJ · Isoform flip of glutamate receptor 2,VOLTAGE-dependent…: “Complex nnnn of AMPA-subtype iglur GLUA2 in complex with auxiliary subunit GAMMA2 (stargazin) at low…”. Electron microscopy, 1 ligand (CYZ), 20 pockets (best druggability…
- PDB
- 7TNJ
- Type
- protein
- Length
- 2,402 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform flip of glutamate receptor 2,VOLTAGE-dependent calcium channel gamma-3 subunit…
- UniProt
- Q8VHX0
- Ligands
- CYZ
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 50% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Isoform flip of glutamate receptor 2,VOLTAGE-dependent calcium channel gamma-3 subunit chimera | protein | 599 | 50% helix, 12% strand | Q8VHX0 |
| B, D | Isoform flip of glutamate receptor 2,VOLTAGE-dependent calcium channel gamma-3 subunit chimera | protein | 602 | 51% helix, 12% strand | Q8VHX0 |
Ligands and binding sites
- CYZ · Cyclothiazide · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.84 | 0.85 | 125 | CYZ |
| 2 | 333 | 0.83 | 0.93 | 53 | empty |
| 3 | 704 | 0.82 | 0.86 | 79 | CYZ |
| 4 | 717 | 0.79 | 0.83 | 99 | empty |
| 5 | 700 | 0.75 | 0.81 | 99 | empty |
Interfaces
6 interfaces between chains.
- A–D · 4106 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 4067 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 2976 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 2963 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 157 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 7TNJ · Complex NNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2… · the same entry in another collection · chain D against D, TM-score 1.00
- Q8VHX0 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-3 subunit… · a predicted model of the same protein · chain A against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VHX0
- Elsewhere: RCSB PDB 7TNJ · PDBe 7TNJ · UniProt Q8VHX0
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