UniProt Q8VDS3
Chromobox protein homolog 7 (Q8VDS3)
Chromobox protein homolog 7 (UniProt Q8VDS3): 12 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8VDS3
- Protein
- Chromobox protein homolog 7
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 5 · 2 records with a druggable one
Structures
13 records of Q8VDS3 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KVM | Solution structure of the CBX7 chromodomain in complex with a H3K27me2 peptide | solution nmr | A | — | — |
| 2KVM | Solution structure of the CBX7 chromodomain in complex with a H3K27ME2 peptide | solution nmr | A | — | — |
| 4X3K | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27me3 peptide | x-ray diffraction | A, B | NI, K | 1 (best 0.55) |
| 4X3K | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27ME3 peptide | x-ray diffraction | A, B | — | — |
| 4X3S | Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170me3 Peptide | x-ray diffraction | A, B | — | — |
| 4X3S | Crystal structure of chromobox homology 7 (CBX7) with SETDB1-1170ME3 peptide | x-ray diffraction | A, B | — | — |
| 4X3T | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452 | x-ray diffraction | A, B, C, D, E, F | 45E, ZN | 4 (best 0.73) |
| 4X3T | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS37452 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4X3U | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with Suramin | x-ray diffraction | A, B | — | — |
| 4X3U | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with suramin | x-ray diffraction | A, B | — | — |
| 5EJW | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 | x-ray diffraction | A | 5PZ | — |
| 5EJW | Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 | x-ray diffraction | A | — | — |
| Q8VDS3 | AlphaFold monomer V2.0 prediction for chromobox protein homolog 7 (Q8VDS3) | predicted | A | — | — |
Ligands
- 45E · 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone · in 1 record
- 5PZ · (1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol · in 1 record
- K · Potassium ion · in 1 record
- NI · Nickel (II) ion · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 4X3S chain A against the predicted model Q8VDS3: TM-score 0.92, RMSD 0.98 Å
- 4X3S chain A against the predicted model Q8VDS3: TM-score 0.92, RMSD 0.98 Å
- 4X3S chain B against the predicted model Q8VDS3: TM-score 0.91, RMSD 0.98 Å
- 4X3S chain B against the predicted model Q8VDS3: TM-score 0.91, RMSD 0.98 Å
- 4X3U chain B against the predicted model Q8VDS3: TM-score 0.88, RMSD 1.29 Å
- 4X3U chain B against the predicted model Q8VDS3: TM-score 0.88, RMSD 1.29 Å
- 4X3U chain A against the predicted model Q8VDS3: TM-score 0.86, RMSD 1.32 Å
- 4X3U chain A against the predicted model Q8VDS3: TM-score 0.86, RMSD 1.32 Å
- 4X3K chain A against the predicted model Q8VDS3: TM-score 0.86, RMSD 0.95 Å
- 4X3K chain A against the predicted model Q8VDS3: TM-score 0.86, RMSD 0.95 Å
Elsewhere
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