UniProt Q8R5F7
Interferon-induced helicase C domain-containing protein 1 (Q8R5F7)
Interferon-induced helicase C domain-containing protein 1 (UniProt Q8R5F7), EC 3.6.4.13: 23 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 49 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8R5F7
- Protein
- Interferon-induced helicase C domain-containing protein 1
- EC
- 3.6.4.13
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 49 · 4 records with a druggable one
Structures
24 records of Q8R5F7 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3TS9 | Crystal Structure of the MDA5 Helicase Insert Domain | x-ray diffraction | A | — | — |
| 3TS9 | Crystal structure of the MDA5 helicase insert domain | x-ray diffraction | A | — | — |
| 6G19 | Cryoem structure of the MDA5-dsrna filament with 74-degree helical twist | electron microscopy | A | ZN, ANP | — |
| 6G1S | CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist | electron microscopy | A | ZN | 13 (best 0.87) |
| 6G1S | Cryoem structure of the MDA5-dsrna filament with 87-degree helical twist | electron microscopy | A | ZN | — |
| 6G1X | CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist | electron microscopy | A | ZN | 13 (best 0.85) |
| 6G1X | Cryoem structure of the MDA5-dsrna filament with 91-degree helical twist | electron microscopy | A | ZN | — |
| 6GJZ | Cryoem structure of the MDA5-dsrna filament in complex with amppnp | electron microscopy | A | ZN, ANP | — |
| 6GKH | CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4 | electron microscopy | A | ADP, ALF, MG, ZN | 13 (best 0.85) |
| 6GKH | Cryoem structure of the MDA5-dsrna filament in complex with ADP-ALF4 | electron microscopy | A | ADP, ALF, MG, ZN | — |
| 6GKM | CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM) | electron microscopy | A | ZN, ATP | — |
| 6GKM | Cryoem structure of the MDA5-dsrna filament in complex with ATP (10 mm) | electron microscopy | A | ZN, ATP | — |
| 6H61 | CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide | electron microscopy | A | ZN | — |
| 6H61 | Cryoem structure of the MDA5-dsrna filament with 89 degree twist and without nucleotide | electron microscopy | A | ZN | — |
| 6H66 | CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide | electron microscopy | A | ZN | — |
| 6H66 | Cryoem structure of the MDA5-dsrna filament with 93 degree twist and without nucleotide | electron microscopy | A | ZN | — |
| 7BKP | Cryoem structure of disease related M854K MDA5-dsrna filament in complex with ATP | electron microscopy | A | ZN, ATP, MG | — |
| 7BKQ | CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist | electron microscopy | A | ZN, ADP | — |
| 7BKQ | Cryoem structure of MDA5-dsrna filament in complex with ADP with 92- degree helical twist | electron microscopy | A | ZN, ADP | — |
| 7NGA | CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist | electron microscopy | A | ZN, ADP | 10 (best 0.83) |
| 7NGA | Cryoem structure of the MDA5-dsrna filament in complex with ADP with 88-degree helical twist | electron microscopy | A | ZN, ADP | — |
| 7NIC | Cryoem structure of disease related M854K MDA5-dsrna filament in complex with ADP-ALF4(MINOR class) | electron microscopy | A | ADP, ALF, ZN | — |
| 7NIQ | Cryoem structure of disease related M854K MDA5-dsrna filament in complex with ADP-ALF4(MAJOR class) | electron microscopy | B | ADP, ALF, ZN | — |
| Q8R5F7 | AlphaFold monomer V2.0 prediction for interferon-induced helicase C domain-containing protein 1… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6GJZ chain A against the predicted model Q8R5F7: TM-score 0.99, RMSD 1.11 Å
- 6G19 chain A against the predicted model Q8R5F7: TM-score 0.99, RMSD 1.11 Å
- 6GKM chain A against the predicted model Q8R5F7: TM-score 0.99, RMSD 1.13 Å
- 6GKM chain A against the predicted model Q8R5F7: TM-score 0.99, RMSD 1.13 Å
- 7NIQ chain B against the predicted model Q8R5F7: TM-score 0.98, RMSD 1.35 Å
- 6GKH chain A against the predicted model Q8R5F7: TM-score 0.98, RMSD 1.45 Å
- 6GKH chain A against the predicted model Q8R5F7: TM-score 0.98, RMSD 1.45 Å
- 7NIC chain A against the predicted model Q8R5F7: TM-score 0.98, RMSD 1.48 Å
- 7BKP chain A against the predicted model Q8R5F7: TM-score 0.98, RMSD 1.48 Å
- 6H61 chain A against the predicted model Q8R5F7: TM-score 0.97, RMSD 1.56 Å
Elsewhere
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