UniProt Q8NFG4

Folliculin (Q8NFG4)

Folliculin (UniProt Q8NFG4): 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q8NFG4
Protein: Folliculin
Experimental structures: 7
Predicted models: 1
Ligands: 3
Pockets: 23 · 3 records with a druggable one

Structures

8 records of Q8NFG4 in the MolNFT archive: 7 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3V42	Crystal structure of renal tumor suppressor protein, folliculin	x-ray diffraction	A, B	—	—
3V42	Crystal structure of renal tumor suppressor protein, folliculin	x-ray diffraction	A, B	—	—
6NZD	Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)	electron microscopy	H	GDP	10 (best 0.81)
6NZD	Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator)	electron microscopy	H	GDP	—
6ULG	Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex	electron microscopy	L	GDP	9 (best 0.80)
6ULG	Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex	electron microscopy	L	—	—
8DHB	Active FLCN GAP complex	electron microscopy	J	CZC, BEF	4 (best 0.77)
Q8NFG4	AlphaFold monomer V2.0 prediction for folliculin (Q8NFG4)	predicted	A	—	—

Ligands

GDP · Guanosine-5'-diphosphate · in 3 records
BEF · Beryllium trifluoride ion · in 1 record
CZC · [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate · in 1 record

Experiment against prediction

3V42 chain A against the predicted model Q8NFG4: TM-score 0.97, RMSD 1.05 Å
3V42 chain A against the predicted model Q8NFG4: TM-score 0.97, RMSD 1.05 Å
3V42 chain B against the predicted model Q8NFG4: TM-score 0.96, RMSD 1.38 Å
3V42 chain B against the predicted model Q8NFG4: TM-score 0.96, RMSD 1.38 Å
8DHB chain J against the predicted model Q8NFG4: TM-score 0.55, RMSD 3.38 Å
6NZD chain H against the predicted model Q8NFG4: TM-score 0.51, RMSD 2.12 Å
6NZD chain H against the predicted model Q8NFG4: TM-score 0.51, RMSD 2.12 Å
6ULG chain L against the predicted model Q8NFG4: TM-score 0.50, RMSD 2.85 Å
6ULG chain L against the predicted model Q8NFG4: TM-score 0.50, RMSD 2.85 Å

Elsewhere

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