UniProt Q8NER1
Transient receptor potential cation channel subfamily V member 1 (Q8NER1)
Transient receptor potential cation channel subfamily V member 1 (UniProt Q8NER1): 7 experimental structures on GenesisL1, 7 ligands bound, 100 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8NER1
- Protein
- Transient receptor potential cation channel subfamily V member 1
- Experimental structures
- 7
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 100 · 5 records with a druggable one
Structures
7 records of Q8NER1 in the MolNFT archive: 7 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L93 | X-ray structure of the ligand-free human TRPV1 ankyrin repeat domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8GF8 | Cryo-EM structure of human TRPV1 in cNW11 nanodisc and soybean lipids | electron microscopy | A, B, C, D | POV, 8IJ, NA | 20 (best 0.81) |
| 8GF9 | Cryo-EM structure of human TRPV1 in cNW11 nanodisc and POPC:POPE:POPG lipids | electron microscopy | A, B, C, D | POV, 8IJ, NA | 20 (best 0.81) |
| 8GFA | Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | electron microscopy | A, B, C, D | POV, ZEI, DU0, NA | 20 (best 0.83) |
| 8JQR | Structure of human TRPV1 in complex with antagonist | electron microscopy | A, B, C, D | EZI, CLR | 20 (best 0.83) |
| 8X94 | Structure of human TRPV1 in complex with antagonist --protein purified without CHS | electron microscopy | A, B, C, D | EZI, CLR | 20 (best 0.86) |
| Q8NER1 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V… | — | — | — |
Ligands
- NA · Sodium ion · in 3 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 3 records
- 8IJ · (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate · in 2 records
- CLR · Cholesterol · in 2 records
- EZI · 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile · in 2 records
- DU0 · 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R}, 9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4, 8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol · in 1 record
- ZEI · (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide · in 1 record
Elsewhere
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