UniProt Q8IFM8
Cysteine-rich protective antigen (Q8IFM8)
Cysteine-rich protective antigen (UniProt Q8IFM8): 21 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 104 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8IFM8
- Protein
- Cysteine-rich protective antigen
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 104 · 10 records with a druggable one
Structures
22 records of Q8IFM8 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5EZN | Crystal Structure of PfCyRPA | x-ray diffraction | A, E, B, G | — | 8 (best 0.85) |
| 5EZN | Crystal structure of pfcyrpa | x-ray diffraction | A, E, B, G | — | — |
| 5EZO | Crystal Structure of PfCyRPA in complex with an invasion-inhibitory antibody Fab. | x-ray diffraction | A | — | — |
| 5EZO | Crystal structure of pfcyrpa in complex with an invasion-inhibitory antibody Fab. | x-ray diffraction | A | — | — |
| 5TIH | Structural basis for inhibition of erythrocyte invasion by antibodies to plasmodium falciparum… | x-ray diffraction | A | — | — |
| 5TIK | Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum… | x-ray diffraction | A, B, C, D | — | 15 (best 0.79) |
| 5TIK | Structural basis for inhibition of erythrocyte invasion by antibodies to plasmodium falciparum… | x-ray diffraction | A, B, C, D | — | — |
| 6MPV | Cryo-electron microscopy structure of Plasmodium falciparum Rh5/CyRPA/Ripr invasion complex | electron microscopy | A | — | 10 (best 0.78) |
| 6MPV | Cryo-electron microscopy structure of plasmodium falciparum RH5/CYRPA/RIPR invasion complex | electron microscopy | A | — | — |
| 7PHV | PfCyRPA bound to monoclonal antibody Cy.007 Fab fragment | x-ray diffraction | A, D | — | 13 (best 0.78) |
| 7PHV | Pfcyrpa bound to monoclonal antibody CY.007 Fab fragment | x-ray diffraction | A, D | — | — |
| 7PHW | PfCyRPA bound to monoclonal antibody Cy.004 Fab fragment | x-ray diffraction | A, D | CA | 11 (best 0.77) |
| 7PHW | Pfcyrpa bound to monoclonal antibody CY.004 Fab fragment | x-ray diffraction | A, D | CA | — |
| 7PI2 | PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment | x-ray diffraction | A, D, G, J | — | 10 (best 0.78) |
| 7PI2 | Pfcyrpa bound to monoclonal antibody CY.003 Fab fragment | x-ray diffraction | A, D, G, J | — | — |
| 7PI3 | PfCyRPA bound to Fab fragments from monoclonal antibodies Cy.003, Cy.004 and Cy.007 | x-ray diffraction | A, H, O, V | CA | 15 (best 0.83) |
| 7PI3 | Pfcyrpa bound to Fab fragments from monoclonal antibodies CY.003, CY.004 and CY.007 | x-ray diffraction | A, H, O, V | CA | — |
| 7PI7 | PfCyRPA bound to monoclonal antibody Cy.002 Fab fragment | x-ray diffraction | A, D | — | 11 (best 0.83) |
| 7PI7 | Pfcyrpa bound to monoclonal antibody CY.002 Fab fragment | x-ray diffraction | A, D | — | — |
| 8CDD | PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 | electron microscopy | B | — | 8 (best 0.77) |
| 8CDE | PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003 | electron microscopy | B | — | 3 (best 0.75) |
| Q8IFM8 | AlphaFold monomer V2.0 prediction for cysteine-rich protective antigen (Q8IFM8) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
Experiment against prediction
- 5TIH chain A against the predicted model Q8IFM8: TM-score 0.99, RMSD 0.52 Å
- 7PI2 chain D against the predicted model Q8IFM8: TM-score 0.99, RMSD 0.77 Å
- 7PI2 chain D against the predicted model Q8IFM8: TM-score 0.99, RMSD 0.77 Å
- 5TIK chain A against the predicted model Q8IFM8: TM-score 0.99, RMSD 0.79 Å
- 5TIK chain A against the predicted model Q8IFM8: TM-score 0.99, RMSD 0.79 Å
- 7PHV chain D against the predicted model Q8IFM8: TM-score 0.98, RMSD 0.91 Å
- 7PHV chain D against the predicted model Q8IFM8: TM-score 0.98, RMSD 0.91 Å
- 7PHW chain A against the predicted model Q8IFM8: TM-score 0.98, RMSD 0.89 Å
- 7PHW chain A against the predicted model Q8IFM8: TM-score 0.98, RMSD 0.89 Å
- 7PI2 chain A against the predicted model Q8IFM8: TM-score 0.98, RMSD 1.03 Å
Elsewhere
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