MolNFT v1 · #134896 · protein
Structural basis for inhibition of erythrocyte invasion by antibodies to plasmodium falciparum protein cyrpa
5TIK · Cysteine-rich protective antigen: “Structural basis for inhibition of erythrocyte invasion by antibodies to plasmodium falciparum protein cyrpa”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #134896 on…
- PDB
- 5TIK
- Type
- protein
- Length
- 1,273 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine-rich protective antigen
- UniProt
- Q8IFM8
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 1% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine-rich protective antigen | protein | 310 | 1% helix, 56% strand | Q8IFM8 |
| B | Cysteine-rich protective antigen | protein | 324 | 1% helix, 56% strand | Q8IFM8 |
| C | Cysteine-rich protective antigen | protein | 321 | 1% helix, 57% strand | Q8IFM8 |
| D | Cysteine-rich protective antigen | protein | 318 | 1% helix, 60% strand | Q8IFM8 |
Pockets
15 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 731 | 0.79 | 0.83 | 75 | empty |
| 2 | 981 | 0.79 | 0.81 | 95 | empty |
| 3 | 624 | 0.78 | 0.84 | 65 | empty |
| 4 | 634 | 0.78 | 0.84 | 71 | empty |
| 5 | 556 | 0.77 | 0.84 | 65 | empty |
Interfaces
6 interfaces between chains.
- A–B · 840 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 823 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 622 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 617 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 98 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 5TIK · Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium… · the same entry in another collection · chain D against D, TM-score 1.00
- Q8IFM8 · AlphaFold monomer V2.0 prediction for cysteine-rich protective antigen (Q8IFM8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IFM8
- Elsewhere: RCSB PDB 5TIK · PDBe 5TIK · UniProt Q8IFM8
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