Research workbench
Structural basis for inhibition of erythrocyte invasion by antibodies to plasmodium falciparum protein cyrpa
Analyse Structural basis for inhibition of erythrocyte invasion by antibodies to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TIK
- Type
- protein
- Length
- 1,273 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine-rich protective antigen
- UniProt
- Q8IFM8
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 1% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine-rich protective antigen | protein | 310 | 1% helix, 56% strand | Q8IFM8 |
| B | Cysteine-rich protective antigen | protein | 324 | 1% helix, 56% strand | Q8IFM8 |
| C | Cysteine-rich protective antigen | protein | 321 | 1% helix, 57% strand | Q8IFM8 |
| D | Cysteine-rich protective antigen | protein | 318 | 1% helix, 60% strand | Q8IFM8 |
Pockets
15 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 731 | 0.79 | 0.83 | 75 | empty |
| 2 | 981 | 0.79 | 0.81 | 95 | empty |
| 3 | 624 | 0.78 | 0.84 | 65 | empty |
| 4 | 634 | 0.78 | 0.84 | 71 | empty |
| 5 | 556 | 0.77 | 0.84 | 65 | empty |
Interfaces
6 interfaces between chains.
- A–B · 840 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 823 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 622 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 617 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 98 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 5TIK · Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium… · the same entry in another collection · chain D against D, TM-score 1.00
- Q8IFM8 · AlphaFold monomer V2.0 prediction for cysteine-rich protective antigen (Q8IFM8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IFM8
- Elsewhere: RCSB PDB 5TIK · PDBe 5TIK · UniProt Q8IFM8
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