UniProt Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (UniProt Q7Z6Z7), EC 2.3.2.26, 6.3.2.-: 31 experimental structures on GenesisL1, 10 ligands bound, 129 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q7Z6Z7
- Protein
- E3 ubiquitin-protein ligase HUWE1
- EC
- 2.3.2.26, 6.3.2.-
- Experimental structures
- 31
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 129 · 10 records with a druggable one
Structures
31 records of Q7Z6Z7 in the MolNFT archive: 31 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EKK | Solution structure of RUH-074, a human UBA domain | solution nmr | A | — | — |
| 2EKK | Solution structure of ruh-074, a human uba domain | solution nmr | A | — | — |
| 2MUL | Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1 | solution nmr | A | — | — |
| 2MUL | Solution structure of the UBM1 domain of human HUWE1/ARF-BP1 | solution nmr | A | — | — |
| 3G1N | Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1 | x-ray diffraction | A, B | — | — |
| 3G1N | Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1 | x-ray diffraction | A, B | — | — |
| 3H1D | Structure of the HUWE1 HECT Domain | x-ray diffraction | A | — | — |
| 3H1D | Structure of the HUWE1 hect domain | x-ray diffraction | A | — | — |
| 5C6H | Mcl-1 complexed with mule | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 5LP8 | Crystal structure of an asymmetric dimer of the ubiquitin ligase HUWE1 | x-ray diffraction | B, A | — | 10 (best 0.80) |
| 5LP8 | Crystal structure of an asymmetric dimer of the ubiquitin ligase HUWE1 | x-ray diffraction | B, A | — | — |
| 6FYH | Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1 | x-ray diffraction | A | SO4, ZN | 2 (best 0.32) |
| 6FYH | Disulfide between ubiquitin G76C and the E3 hect ligase HUWE1 | x-ray diffraction | A | SO4, ZN | — |
| 6MIW | WWE domain of human HUWE1 | x-ray diffraction | A | UNX | — |
| 6MIW | Wwe domain of human HUWE1 | x-ray diffraction | A | UNX | — |
| 6PFL | Crystal structure of Human HUWE1 WWE domain in complex with ADPR | x-ray diffraction | A, B | APR, UNX | 1 (best 0.41) |
| 6PFL | Crystal structure of human HUWE1 wwe domain in complex with adpr | x-ray diffraction | A, B | APR, UNX | — |
| 7JQ9 | Cryo-EM structure of human HUWE1 | electron microscopy | A | — | 20 (best 0.77) |
| 7JQ9 | Cryo-EM structure of human HUWE1 | electron microscopy | A | — | — |
| 7MOP | Cryo-EM structure of human HUWE1 in complex with DDIT4 | electron microscopy | A | — | 20 (best 0.84) |
| 7MOP | Cryo-EM structure of human HUWE1 in complex with DDIT4 | electron microscopy | A | — | — |
| 7MWD | HUWE1 in map with focus on HECT | electron microscopy | A | — | 20 (best 0.77) |
| 7MWD | HUWE1 in MAP with focus on hect | electron microscopy | A | — | — |
| 7MWE | HUWE1 in map with focus on WWE | electron microscopy | A | — | 20 (best 0.76) |
| 7MWE | HUWE1 in MAP with focus on wwe | electron microscopy | A | — | — |
| 7MWF | HUWE1 in map with focus on interface | electron microscopy | A | — | 20 (best 0.76) |
| 7MWF | HUWE1 in MAP with focus on interface | electron microscopy | A | — | — |
| 8R7O | HUWE1 WWE domain in complex with 2'F-ATP | x-ray diffraction | A, B, C, D | CL, YGC, NA | 3 (best 0.69) |
| 8RD0 | HUWE1 WWE domain in complex with compound 3 | x-ray diffraction | A, B, C, D | CL, 51X | 4 (best 0.67) |
| 8RD1 | HUWE1 WWE domain in complex with compound 4 | x-ray diffraction | A, B, C, D | CL, YP2 | 5 (best 0.71) |
| 8RD7 | HUWE1 WWE domain in complex with ADP-ribose | x-ray diffraction | A, B, C, D | CL, AR6 | 4 (best 0.78) |
Ligands
- CL · Chloride ion · in 4 records
- UNX · Unknown atom or ion · in 4 records
- APR · Adenosine-5-diphosphoribose · in 2 records
- SO4 · Sulfate ion · in 2 records
- ZN · Zinc ion · in 2 records
- 51X · (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid · in 1 record
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · in 1 record
- NA · Sodium ion · in 1 record
- YGC · [[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-fluoranyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 1 record
- YP2 · 2-(2-hydroxy-2-oxoethyl)-1,3-bis(oxidanylidene)isoindole-5-carboxylic acid · in 1 record
Elsewhere
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