MolNFT v1 · #178935 · protein
Cryo-EM structure of human HUWE1
7JQ9 · E3 ubiquitin-protein ligase HUWE1: “Cryo-EM structure of human HUWE1”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #178935 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7JQ9
- Type
- protein
- Length
- 2,427 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase HUWE1
- EC
- 2.3.2.26
- UniProt
- Q7Z6Z7
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 65% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) | protein | 2427 | 65% helix, 5% strand | Q7Z6Z7 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1008 | 0.77 | 0.79 | 98 | empty |
| 2 | 374 | 0.62 | 0.78 | 37 | empty |
| 3 | 100 | 0.62 | 0.88 | 32 | empty |
| 4 | 53 | 0.61 | 0.93 | 20 | empty |
| 5 | 301 | 0.60 | 0.78 | 41 | empty |
Compared structures
- 7JQ9 · Cryo-EM structure of human HUWE1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z6Z7
- Elsewhere: RCSB PDB 7JQ9 · PDBe 7JQ9 · UniProt Q7Z6Z7
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