UniProt Q7Z3F1
Integral membrane protein GPR155 (Q7Z3F1)
Integral membrane protein GPR155 (UniProt Q7Z3F1): 9 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 99 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7Z3F1
- Protein
- Integral membrane protein GPR155
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 99 · 10 records with a druggable one
Structures
10 records of Q7Z3F1 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8U54 | The mTORC1 cholesterol sensor LYCHOS (GPR155) | electron microscopy | A, B | NAG | 16 (best 0.81) |
| 8U56 | The mTORC1 cholesterol sensor LYCHOS (GPR155) | electron microscopy | A, B | LMN, Y01 | 9 (best 0.82) |
| 8U58 | The mTORC1 cholesterol sensor LYCHOS (GPR155) with tryptophan | electron microscopy | C, A | NAG | 10 (best 0.80) |
| 8U5C | The mTORC1 cholesterol sensor LYCHOS (GPR155) with cholesterol | electron microscopy | E, F | Y01 | 12 (best 0.81) |
| 8U5N | The mTORC1 cholesterol sensor LYCHOS (GPR155) - monomer with auxin | electron microscopy | A | IAC | 4 (best 0.70) |
| 8U5Q | The mTORC1 cholesterol sensor LYCHOS (GPR155) - dimer with auxin | electron microscopy | A, C | IAC | 13 (best 0.79) |
| 8U5V | The mTORC1 cholesterol sensor LYCHOS (GPR155) - auxin bound, closed state | electron microscopy | A | IAC, Y01 | 4 (best 0.81) |
| 8U5X | The mTORC1 cholesterol sensor LYCHOS (GPR155) - auxin bound, open state | electron microscopy | A | IAC | 6 (best 0.74) |
| 8Z8Z | Cryo-EM structure of LYCHOS | electron microscopy | A, B | NAG, 6OU, CLR, A1L1C, LBN, NA | 13 (best 0.83) |
| Q7Z3F1 | AlphaFold monomer V2.0 prediction for integral membrane protein GPR155 (Q7Z3F1) | predicted | A | — | 12 (best 0.80) |
Ligands
- IAC · 1H-indol-3-ylacetic acid · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 1 record
- A1L1C · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (4~{Z},7~{Z},10~{Z},13~{Z},16~{Z},19~{Z})-docosa-4,7,10,13,16,19-hexaenoate · in 1 record
- CLR · Cholesterol · in 1 record
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 1 record
- LMN · Lauryl Maltose Neopentyl Glycol · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 8U5Q chain A against the predicted model Q7Z3F1: TM-score 0.73, RMSD 3.73 Å
- 8U56 chain A against the predicted model Q7Z3F1: TM-score 0.68, RMSD 4.85 Å
- 8U56 chain B against the predicted model Q7Z3F1: TM-score 0.68, RMSD 4.85 Å
- 8U5V chain A against the predicted model Q7Z3F1: TM-score 0.68, RMSD 4.68 Å
- 8U58 chain C against the predicted model Q7Z3F1: TM-score 0.66, RMSD 4.78 Å
- 8U5X chain A against the predicted model Q7Z3F1: TM-score 0.66, RMSD 3.74 Å
- 8Z8Z chain A against the predicted model Q7Z3F1: TM-score 0.66, RMSD 4.91 Å
- 8Z8Z chain B against the predicted model Q7Z3F1: TM-score 0.66, RMSD 4.91 Å
- 8U5N chain A against the predicted model Q7Z3F1: TM-score 0.65, RMSD 3.97 Å
- 8U5C chain E against the predicted model Q7Z3F1: TM-score 0.64, RMSD 5.20 Å
Elsewhere
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