UniProt Q6P9J9
Anoctamin-6 (Q6P9J9)
Anoctamin-6 (UniProt Q6P9J9): 24 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 304 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6P9J9
- Protein
- Anoctamin-6
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 304 · 16 records with a druggable one
Structures
25 records of Q6P9J9 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6P46 | Cryo-EM structure of TMEM16F in digitonin with calcium bound | electron microscopy | A, B | CA | 20 (best 0.77) |
| 6P46 | Cryo-EM structure of TMEM16F in digitonin with calcium bound | electron microscopy | A, B | CA | — |
| 6P47 | Cryo-EM structure of TMEM16F in digitonin without calcium | electron microscopy | A, B | — | 20 (best 0.79) |
| 6P47 | Cryo-EM structure of TMEM16F in digitonin without calcium | electron microscopy | A, B | — | — |
| 6P48 | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1 | electron microscopy | A, B | CA | 20 (best 0.72) |
| 6P48 | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in CL1 | electron microscopy | A, B | CA | — |
| 6P49 | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2 | electron microscopy | A, B | CA | 20 (best 0.79) |
| 6P49 | Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in CL2 | electron microscopy | A, B | CA | — |
| 6QP6 | Cryo-EM structure of calcium-bound MTMEM16F lipid scramblase in digitonin | electron microscopy | A, B | CA, P1O | — |
| 6QPB | Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in digitonin | electron microscopy | A, B | P1O | 20 (best 0.82) |
| 6QPB | Cryo-EM structure of calcium-free MTMEM16F lipid scramblase in digitonin | electron microscopy | A, B | P1O | — |
| 6QPC | Cryo-EM structure of calcium-bound MTMEM16F lipid scramblase in nanodisc | electron microscopy | A, B | CA, P1O | — |
| 6QPI | Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc | electron microscopy | A, B | — | 4 (best 0.77) |
| 6QPI | Cryo-EM structure of calcium-free MTMEM16F lipid scramblase in nanodisc | electron microscopy | A, B | — | — |
| 8B8J | Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin | electron microscopy | A, B | CA | 20 (best 0.84) |
| 8B8K | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed | electron microscopy | A, B | CA, P1O | 20 (best 0.79) |
| 8B8M | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed | electron microscopy | A, B | CA | 20 (best 0.83) |
| 8B8Q | Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | electron microscopy | A, B | CA | 20 (best 0.82) |
| 8BC1 | Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN | electron microscopy | A, B | CA | 20 (best 0.75) |
| 8SUN | TMEM16F 1PBC | electron microscopy | A, B | NAG, CA, JRF | 20 (best 0.80) |
| 8SUR | TMEM16F bound with Niclosamide | electron microscopy | A, B | NAG, CA, VUT | 20 (best 0.83) |
| 8TAG | TMEM16F, with Calcium and PIP2, no inhibitor | electron microscopy | A, B | NAG, CA | 20 (best 0.79) |
| 8TAI | TMEM16F, with Calcium and PIP2, no inhibitor, Cl2 | electron microscopy | A, B | NAG, CA | 20 (best 0.80) |
| 8TAL | TMEM16F, with Calcium and PIP2, no inhibitor, Cl1 | electron microscopy | A, B | NAG, CA | 20 (best 0.81) |
| Q6P9J9 | AlphaFold monomer V2.0 prediction for anoctamin-6 (Q6P9J9) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 18 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- P1O · 1,2-didecanoyl-sn-glycero-3-phosphocholine · in 5 records
- JRF · 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile · in 1 record
- VUT · 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide · in 1 record
Experiment against prediction
- 8B8M chain B against the predicted model Q6P9J9: TM-score 0.96, RMSD 1.94 Å
- 8B8Q chain A against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.23 Å
- 8B8Q chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.24 Å
- 8SUR chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.39 Å
- 6QPC chain A against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.21 Å
- 6QPC chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.21 Å
- 8TAI chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.56 Å
- 8TAL chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.56 Å
- 8TAG chain B against the predicted model Q6P9J9: TM-score 0.95, RMSD 2.51 Å
- 8SUN chain B against the predicted model Q6P9J9: TM-score 0.94, RMSD 2.64 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.