MolNFT v1 · #161799 · protein

Cryo-EM structure of calcium-free MTMEM16F lipid scramblase in nanodisc

6QPI · Anoctamin-6: “Cryo-EM structure of calcium-free MTMEM16F lipid scramblase in nanodisc”. Electron microscopy, 4 pockets (best druggability 0.77). MolNFT v1 #161799 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6QPI
Type: protein
Length: 462 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anoctamin-6
UniProt: Q6P9J9
Pockets: 4 · best druggability 0.77

Structure

electron microscopy · 1 distinct chain · 88% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Anoctamin-6	protein	231	88% helix, 0% strand	Q6P9J9

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	913	0.77	0.80	94	empty
2	1172	0.73	0.76	114	empty
3	99	0.39	0.76	25	empty
4	90	0.37	0.76	26	empty

Interfaces

1 interface between chains.

A–B · 128 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6QPI · Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc · the same entry in another collection · chain A against A, TM-score 1.00
Q6P9J9 · AlphaFold monomer V2.0 prediction for anoctamin-6 (Q6P9J9) · a predicted model of the same protein · chain B against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P9J9
Elsewhere: RCSB PDB 6QPI · PDBe 6QPI · UniProt Q6P9J9

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