UniProt Q6DLV0
Genome polyprotein (Q6DLV0)
Genome polyprotein (UniProt Q6DLV0), EC 2.7.7.48: 46 experimental structures on GenesisL1, 16 ligands bound, 32 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q6DLV0
- Protein
- Genome polyprotein
- EC
- 2.7.7.48
- Experimental structures
- 46
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 32 · 6 records with a druggable one
Structures
46 records of Q6DLV0 in the MolNFT archive: 46 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2J7U | Dengue virus NS5 RNA dependent RNA polymerase domain | x-ray diffraction | A | — | — |
| 2J7U | Dengue virus NS5 RNA dependent RNA polymerase domain | x-ray diffraction | A | — | — |
| 2J7W | Dengue virus NS5 RNA dependent RNA polymerase domain complexed with 3' dGTP | x-ray diffraction | A | ZN, GTP | 6 (best 0.69) |
| 2J7W | Dengue virus NS5 RNA dependent RNA polymerase domain complexed with 3'DGTP | x-ray diffraction | A | — | — |
| 3J6S | Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C | electron microscopy | A, B, C, D, E, F | — | — |
| 3J6S | Cryo-EM structure of dengue virus serotype 3 at 28 degrees C | electron microscopy | A, B, C, D, E, F | — | — |
| 3J6T | Cryo-EM structure of Dengue virus serotype 3 at 37 degrees C | electron microscopy | A, B, C, D, E, F | — | — |
| 3J6T | Cryo-EM structure of dengue virus serotype 3 at 37 degrees C | electron microscopy | A, B, C, D, E, F | — | — |
| 3J6U | Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab | electron microscopy | A, B, C, D, E, F | — | — |
| 3J6U | Cryo-EM structure of dengue virus serotype 3 in complex with human antibody 5J7 Fab | electron microscopy | A, B, C, D, E, F | — | — |
| 3VWS | Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107 | x-ray diffraction | A | — | — |
| 3VWS | Dengue serotype 3 RNA-dependent RNA polymerase bound to nitd-107 | x-ray diffraction | A | — | — |
| 4C11 | Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region | x-ray diffraction | A, B | — | — |
| 4C11 | Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region | x-ray diffraction | A, B | — | — |
| 4HHJ | Dengue serotype 3 RNA-dependent RNA polymerase | x-ray diffraction | A | — | — |
| 4HHJ | Dengue serotype 3 RNA-dependent RNA polymerase | x-ray diffraction | A | — | — |
| 4V0Q | Dengue Virus Full Length NS5 Complexed with SAH | x-ray diffraction | A | — | — |
| 4V0Q | Dengue virus full length NS5 complexed with sah | x-ray diffraction | A | — | — |
| 4V0R | Dengue virus full length NS5 complexed with GTP and sah | x-ray diffraction | A | — | — |
| 4V0R | Dengue virus full length NS5 complexed with GTP and sah | x-ray diffraction | A | — | — |
| 5F3T | Dengue serotype 3 RNA-dependent RNA polymerase bound to JF-31-MG46 | x-ray diffraction | A | ZN, 5UH | — |
| 5F3T | Dengue serotype 3 RNA-dependent RNA polymerase bound to jf-31-MG46 | x-ray diffraction | A | — | — |
| 5F3Z | Dengue serotype 3 RNA-dependent RNA polymerase bound to PC-79-SH52 | x-ray diffraction | A | ZN, 5V5 | — |
| 5F3Z | Dengue serotype 3 RNA-dependent RNA polymerase bound to pc-79-SH52 | x-ray diffraction | A | — | — |
| 5F41 | Dengue serotype 3 RNA-dependent RNA polymerase bound to fd-83-KI26 | x-ray diffraction | A | ZN, 5V6 | — |
| 5F41 | Dengue serotype 3 RNA-dependent RNA polymerase bound to fd-83-KI26 | x-ray diffraction | A | — | — |
| 5HMW | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | x-ray diffraction | A | ZN, LNW | 5 (best 0.70) |
| 5HMW | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | x-ray diffraction | A | — | — |
| 5HMX | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 | x-ray diffraction | A | ZN, LNX | — |
| 5HMX | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 | x-ray diffraction | A | — | — |
| 5HMY | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | x-ray diffraction | A | ZN, LNY | 4 (best 0.73) |
| 5HMY | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | x-ray diffraction | A | — | — |
| 5HMZ | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 | x-ray diffraction | A | ZN, LNZ | — |
| 5HMZ | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 | x-ray diffraction | A | — | — |
| 5HN0 | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 | x-ray diffraction | A | ZN, LNN | — |
| 5HN0 | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 | x-ray diffraction | A | — | — |
| 5I3P | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 27 | x-ray diffraction | A | ZN, 68T | 5 (best 0.70) |
| 5I3P | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 27 | x-ray diffraction | A | — | — |
| 5I3Q | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 29 | x-ray diffraction | A | ZN, 68E | — |
| 5I3Q | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 29 | x-ray diffraction | A | — | — |
| 5IQ6 | Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new… | x-ray diffraction | A | ZN, 6CJ | 5 (best 0.67) |
| 5IQ6 | Crystal structure of dengue virus serotype 3 RNA dependent RNA polymerase bound to HEE1-2TYR, a new… | x-ray diffraction | A | — | — |
| 5JJR | Dengue 3 NS5 protein with compound 29 | x-ray diffraction | A | ZN, SAH, 68E, MG | 7 (best 0.79) |
| 5JJR | Dengue 3 NS5 protein with compound 29 | x-ray diffraction | A | — | — |
| 5JJS | Dengue 3 NS5 protein with compound 27 | x-ray diffraction | A | ZN, 6L2, MG | — |
| 5JJS | Dengue 3 NS5 protein with compound 27 | x-ray diffraction | A | — | — |
Ligands
- ZN · Zinc ion · in 14 records
- 68E · 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide · in 2 records
- MG · Magnesium ion · in 2 records
- 5UH · 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid · in 1 record
- 5V5 · 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid · in 1 record
- 5V6 · 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid · in 1 record
- 68T · 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide · in 1 record
- 6CJ · N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine · in 1 record
- 6L2 · 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide · in 1 record
- GTP · Guanosine-5'-triphosphate · in 1 record
- LNN · (6-hydroxybiphenyl-3-yl)acetic acid · in 1 record
- LNW · 2,2'-biphenyl-3,5-diyldiacetic acid · in 1 record
- LNX · 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid · in 1 record
- LNY · 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid · in 1 record
- LNZ · 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide · in 1 record
- SAH · S-adenosyl-L-homocysteine · in 1 record
Elsewhere
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